| Preparation of a lipid a derivative that contains a 27-hydroxyoctacosanoic acid moiety. | |
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MedLine Citation:
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PMID: 15355045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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[structure: see text] A general synthetic strategy for long-chain omega-1 hydroxy fatty acids has been developed, which employs as a key reaction step a cross metathesis between omega-unsaturated ester and 3-butene-2-ol. The resulting lipids were used for the preparation of lipid A derivatives of Rhizobium sin-1, which have the ability to inhibit the E. coli LPS-dependent synthesis of tumor necrosis factor by human monocytes. |
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Authors:
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Balaji Santhanam; Geert-Jan Boons |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Organic letters Volume: 6 ISSN: 1523-7060 ISO Abbreviation: Org. Lett. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-09 Completed Date: 2005-09-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 3333-6 Citation Subset: IM |
Affiliation:
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Complex Carbohydrate Research Center, The University of Georgia, 315 Riverbend Road, Athens, Georgia 30602, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Escherichia coli
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chemistry,
metabolism Humans Hydroxy Acids / chemical synthesis* Lipid A / analogs & derivatives*, chemical synthesis*, pharmacology Lipopolysaccharides / chemistry, metabolism* Molecular Structure Monocytes / metabolism Rhizobium / chemistry, metabolism Tumor Necrosis Factors / antagonists & inhibitors |
| Grant Support | |
ID/Acronym/Agency:
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P41-RR-5351/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hydroxy Acids; 0/Lipid A; 0/Lipopolysaccharides; 0/Tumor Necrosis Factors; 121822-56-8/27-hydroxyoctacosanoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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