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Preparation of keratin hydrogel/hydroxyapatite composite and its evaluation as a controlled drug release carrier.
MedLine Citation:
PMID:  24907737     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Infection after artificial joint replacement is a serious problem, which requires the re-implantation of prosthesis. To aim at developing bone filling materials having both osteoconductivity and ability as a sustained drug release carrier, composites of wool keratin or carboxymethylated (CM) keratin hydrogels with hydroxyapatite were prepared and evaluated as a sustained drug release carrier. CM-keratin was prepared by the reaction of keratin extracted from wool with iodoacetic acid. Hydrogels were obtained by dropping keratin or CM-keratin solution into CaCl2 solution. The composites were obtained by immersing hydrogels in simulated body fluid (SBF). The introduction of carboxymethyl groups to keratin facilitated the deposition of hydroxyapatite on hydrogel. After 7days of immersion in SBF, a 4-5 times higher amount of hydroxyapatite was accumulated on CM-keratin hydrogel than that on keratin hydrogel. When salicylic acid was loaded on keratin and CM-keratin hydrogels, a good sustained release was observed; that is, 90% of a drug was released up to 14days after 60 and 45% of the initial burst in 1day. On the other hand, initial release within 1day was suppressed by forming a composite with hydroxyapatite and the release was almost ceased at 3days when 60% of the drug was released. Although further improvement to prolong drug release might be necessary, CaKHA and CaCMKHA are expected to be a promising novel type of bone filling materials which has both osteoconductivity and sustained drug release ability.
Authors:
Ryo Nakata; Akira Tachibana; Toshizumi Tanabe
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Publication Detail:
Type:  Journal Article     Date:  2014-04-13
Journal Detail:
Title:  Materials science & engineering. C, Materials for biological applications     Volume:  41     ISSN:  1873-0191     ISO Abbreviation:  Mater Sci Eng C Mater Biol Appl     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-06-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101484109     Medline TA:  Mater Sci Eng C Mater Biol Appl     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
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