| Preparation of insulin-containing microcapsules by a layer-by-layer deposition of concanavalin A and glycogen. | |
| | |
MedLine Citation:
|
PMID: 19441323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The sugar sensitive microcapsules were prepared by a layer-by-layer deposition of concanavalin A (Con A) and glycogen on a calcium carbonate particle containing fluorescein-labeled insulin (F-insulin). The Con A/glycogen multilayer capsules were formed through sugar-lectin interactions by using inner and outer poly(ethyleneimine)/poly(vinyl sulfate) multilayers as supports, while without the supports the microcapsules could not be formed. Fluorescent microscope observations revealed that the capsules thus prepared are spherical in shape with 3-10 microm diameter. The microcapsules released encapsulated F-insulin upon addition of sugars. This is because the added sugars replace glycogen in the binding site of Con A, resulting in the enhanced permeability of the microcapsules to insulin. |
| | |
Authors:
|
Katsuhiko Sato; Daisuke Kodama; Yoshihiro Endo; Jun-ichi Anzai |
Related Documents
:
|
12384133 - Insulin sensitivity correlates with glycogen synthesis rate, but not with von willebran... 6124363 - "in vivo" effects of insulin on carbohydrate metabolism of catfish (ictalurus melas). 12148713 - Conducting community-based, culturally specific, eye disease screening clinics for urba... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of nanoscience and nanotechnology Volume: 9 ISSN: 1533-4880 ISO Abbreviation: J Nanosci Nanotechnol Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2009-05-15 Completed Date: 2009-06-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101088195 Medline TA: J Nanosci Nanotechnol Country: United States |
Other Details:
|
Languages: eng Pagination: 386-90 Citation Subset: IM |
Affiliation:
|
Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Capsules
/
chemistry* Concanavalin A / chemistry* Crystallization / methods Diffusion Drug Carriers / chemistry* Drug Compounding / methods Glycogen / chemistry* Insulin / administration & dosage, chemistry* Materials Testing |
| Chemical | |
Reg. No./Substance:
|
0/Capsules; 0/Drug Carriers; 11028-71-0/Concanavalin A; 11061-68-0/Insulin; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Self-assembly of magnetite nanocrystals with amphiphilic polyethylenimine: structures and applicatio...
Next Document: Electric double-layer capacitance of carbon nanocages.