| Preparation and in vitro/in vivo evaluation of vinpocetine elementary osmotic pump system. | |
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MedLine Citation:
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PMID: 21577257 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Preparation and in vitro and in vivo evaluation of vinpocetine (VIN) elementary osmotic pump (EOP) formulations were investigated. A method for the preparation of VIN elementary osmotic pump tablet was obtained by adding organic acid additives to increase VIN solubility. VIN was used as the active pharmaceutical ingredient, lactose and mannitol as osmotic agent. Citric acid was used as increasing API solubility and without resulting in the API degradation. It is found that the VIN release rate was increasing with the citric acid amount at a constant range. Cellulose acetate 398-3 was employed as semipermeable membrane containing polyethylene glycol 6000 and diethyl-o-phthalate as pore-forming agent and plasticizer for controlling membrane permeability. In addition, a clear difference between the pharmacokinetic patterns of VIN immediate release and VIN elementary osmotic pump formulations was revealed. The area under the plasma concentration-time curve after oral administration of elementary osmotic pump formulations was equivalent to VIN immediate release formulation. Furthermore, significant differences found for mean residence time, elimination half-life, and elimination rate constant values corroborated prolonged release of VIN from elementary osmotic pump formulations. These results suggest that the VIN osmotic pump controlled release tablets have marked controlled release characters and the VIN osmotic pump controlled release tablets and the normal tablets were bioequivalent. |
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Authors:
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Meiying Ning; Yue Zhou; Guojun Chen; Xingguo Mei |
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Publication Detail:
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Type: Journal Article Date: 2011-04-10 |
Journal Detail:
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Title: Advances in pharmacological sciences Volume: 2011 ISSN: 1687-6342 ISO Abbreviation: Adv Pharmacol Sci Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-17 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101537654 Medline TA: Adv Pharmacol Sci Country: United States |
Other Details:
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Languages: eng Pagination: 385469 Citation Subset: - |
Affiliation:
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Novel Drug Delivery and Biomaterial Research Center, National Research Institute for Family Planning, Haidian District Dahuisi Road 12, Beijing 100081, China. |
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