Document Detail

Preparation and in vitro activity of liposome encapsulated opioids.
MedLine Citation:
PMID:  2760779     Owner:  NLM     Status:  MEDLINE    
Four opiate molecules: morphine, naloxone, meperidine and codeine have been encapsulated in liposomes. The encapsulation efficiency has been studied as a function of the following parameters: liposome preparation method, lipid composition and opioid molecule hydrophobicity. The most important parameter as far as the entrapment efficiency is concerned is the liposome preparation method. The opioid activity of these molecules in vitro (Guinea Pig Ileum preparation) has been determined. No differences in the IC50 values could be found between encapsulated and free drug molecules.
F Reig; M A Alsina; M A Busquets; G Valencia; J M Garcia Anton
Related Documents :
1797129 - Perinatal development of inositol synthesis and catabolism in rabbit kidney.
3376149 - Inhibition of human lymphocyte transformation by the macrocyclic trichothecenes roridin...
25190299 - Complementary and alternative medicine use during early pregnancy.
1875329 - Changes in natural killer cell activity in normal pregnant and postpartum women: increa...
12388999 - Levels of plasminogen activators and their inhibitors in maternal and umbilical cord pl...
11668079 - Pregnancy and estradiol decrease gtpase activity in the guinea pig uterine artery.
480319 - A high incidence of abdominal pregnancy in the djungarian hamster (phodopus sungorus).
22028979 - Incidence, management, and outcome of molar pregnancies at a tertiary care hospital in ...
8288749 - A simple, non-invasive method of fallopian tube sperm perfusion.
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of microencapsulation     Volume:  6     ISSN:  0265-2048     ISO Abbreviation:  J Microencapsul     Publication Date:    1989 Jul-Sep
Date Detail:
Created Date:  1989-09-21     Completed Date:  1989-09-21     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  8500513     Medline TA:  J Microencapsul     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Laboratory of Peptides, CID, CSIC, Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chemical Phenomena
Cholesterol / analysis
Codeine / analysis,  pharmacology*
Drug Carriers
Drug Compounding / methods
Guinea Pigs
Meperidine / analysis,  pharmacology*
Morphine / analysis,  pharmacology*
Muscle Contraction / drug effects
Muscle, Smooth / drug effects
Naloxone / analysis,  pharmacology*
Phosphatidylcholines / analysis
Phosphatidylserines / analysis
Reg. No./Substance:
0/Drug Carriers; 0/Liposomes; 0/Phosphatidylcholines; 0/Phosphatidylserines; 465-65-6/Naloxone; 57-27-2/Morphine; 57-42-1/Meperidine; 57-88-5/Cholesterol; 76-57-3/Codeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lack of correlation between in vitro and in vivo activation of complement in mice by infective Trich...
Next Document:  Application of encapsulated enzyme as a continuous packed-bed reactor.