Document Detail

Preparation and in vitro activity of liposome encapsulated opioids.
MedLine Citation:
PMID:  2760779     Owner:  NLM     Status:  MEDLINE    
Four opiate molecules: morphine, naloxone, meperidine and codeine have been encapsulated in liposomes. The encapsulation efficiency has been studied as a function of the following parameters: liposome preparation method, lipid composition and opioid molecule hydrophobicity. The most important parameter as far as the entrapment efficiency is concerned is the liposome preparation method. The opioid activity of these molecules in vitro (Guinea Pig Ileum preparation) has been determined. No differences in the IC50 values could be found between encapsulated and free drug molecules.
F Reig; M A Alsina; M A Busquets; G Valencia; J M Garcia Anton
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of microencapsulation     Volume:  6     ISSN:  0265-2048     ISO Abbreviation:  J Microencapsul     Publication Date:    1989 Jul-Sep
Date Detail:
Created Date:  1989-09-21     Completed Date:  1989-09-21     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  8500513     Medline TA:  J Microencapsul     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Laboratory of Peptides, CID, CSIC, Barcelona, Spain.
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MeSH Terms
Chemical Phenomena
Cholesterol / analysis
Codeine / analysis,  pharmacology*
Drug Carriers
Drug Compounding / methods
Guinea Pigs
Meperidine / analysis,  pharmacology*
Morphine / analysis,  pharmacology*
Muscle Contraction / drug effects
Muscle, Smooth / drug effects
Naloxone / analysis,  pharmacology*
Phosphatidylcholines / analysis
Phosphatidylserines / analysis
Reg. No./Substance:
0/Drug Carriers; 0/Liposomes; 0/Phosphatidylcholines; 0/Phosphatidylserines; 465-65-6/Naloxone; 57-27-2/Morphine; 57-42-1/Meperidine; 57-88-5/Cholesterol; 76-57-3/Codeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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