Document Detail

Preparation of the hypoxia imaging PET tracer [18F]FAZA: reaction parameters and automation.
MedLine Citation:
PMID:  15799867     Owner:  NLM     Status:  MEDLINE    
18F-labeling of the nitroimidazole nucleoside analogue 1-(5-fluoro-5-deoxy-alpha-D-arabinofuranosyl)-2-nitroimidazole (FAZA) was developed to use this tracer in PET for detection of hypoxia. Parameters for labeling and hydrolysis were optimized with regard to amount of precursor, temperature and time. Labeling yields reached a maximum of 62+/-4% at 100 degrees C within 5 min using 5 mg of precursor. Hydrolysis was best performed with 1 mL of 0.1 N NaOH at 20 degrees C for 2 min. Transfer of these conditions to an automated synthesizer resulted in an overall radiochemical yield of 20.7+/-3.5%. Absolute yields at EOS were 9.8+/-2.3 GBq of [18F]FAZA ready for injection (n=21; 50 min after EOB; irradiation parameters: 35 microA, 60 min). Thus, a convenient approach suitable for large-scale production of [18F]FAZA was developed by an automated process.
G Reischl; W Ehrlichmann; C Bieg; C Solbach; P Kumar; L I Wiebe; H-J Machulla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine     Volume:  62     ISSN:  0969-8043     ISO Abbreviation:  Appl Radiat Isot     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-03-31     Completed Date:  2005-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306253     Medline TA:  Appl Radiat Isot     Country:  England    
Other Details:
Languages:  eng     Pagination:  897-901     Citation Subset:  IM    
PET-Zentrum, Radiopharmazie, Universitätsklinikum Tübingen, Röntgenweg 15, Tübingen D-72076, Germany.
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MeSH Terms
Cell Hypoxia*
Fluorine Radioisotopes
Nitroimidazoles / chemistry*
Positron-Emission Tomography*
Radioisotopes / chemistry*
Reg. No./Substance:
0/Fluorine Radioisotopes; 0/Nitroimidazoles; 0/Radioisotopes; 0/fluoroazomycin arabinoside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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