Document Detail

Preparation of heterodifunctional polyethyleneglycols: network formation, characterization, and cell culture analysis.
MedLine Citation:
PMID:  11556739     Owner:  NLM     Status:  MEDLINE    
Polyethyleneglycols (PEG) are employed extensively in the development of biomaterials; however, the hydroxyl groups in PEG-diols have very limited chemical activity. We developed a synthesis scheme for a library of heterodifunctional PEG (hPEG) with two distinct terminal moieties to improve the reactivity and physicochemical properties of PEG. hPEG were employed in the formulation of polymer networks with various surface physicochemical properties and utilized to study cell-material interaction. Extensive NMR and HPLC analyses confirmed the chemical structure of hPEG. The hydrophilicity of the polymer network was predominantly dependent on the hPEG concentration with the molecular weight and terminal functional group playing lesser roles. Adherent human fibroblast density on the network remained constant with increasing hPEG concentration in the network formulation but decreased rapidly on networks containing 0.8-1.25 g ml(-1) of hPEG. This trend was independent of the hPEG terminal moiety and molecular weight. No adherent cell was observed on all films containing 2.5 g ml(-1) or more of hPEG.
W J Kao; D Lok; J Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biomaterials science. Polymer edition     Volume:  12     ISSN:  0920-5063     ISO Abbreviation:  J Biomater Sci Polym Ed     Publication Date:  2001  
Date Detail:
Created Date:  2001-09-14     Completed Date:  2002-01-31     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  9007393     Medline TA:  J Biomater Sci Polym Ed     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  599-611     Citation Subset:  IM    
Division of Pharmaceutical Sciences of the School of Pharmacy, University of Wisconsin Madison, 53706, USA.
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MeSH Terms
Biocompatible Materials / chemistry
Cell Adhesion
Cell Culture Techniques / methods
Cells, Cultured
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
Fibroblasts / metabolism
Magnetic Resonance Spectroscopy
Models, Chemical
Polyethylene Glycols / chemistry*
Polymers / chemistry
Skin / cytology
Time Factors
Grant Support
Reg. No./Substance:
0/Biocompatible Materials; 0/Polyethylene Glycols; 0/Polymers

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