| Preparation, formulation and evaluation of novel photo-cured glass ionomers based on co-polymers of (meth)acrylated amino acids. | |
| | |
MedLine Citation:
|
PMID: 16689017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A novel photo-cured amino-acid-constructed glass-ionomer cement system has been developed. Glutamic acid- and beta-alanine-based methacrylate and acrylate derivatives were synthesized, characterized and used to construct the polyalkenoic acids and formulated with water and Fuji II glass filler to form self-cured cement. Compressive strength (CS) of the cement and viscosity of the liquid were used as tools for evaluation. The effects of molar ratio and molecular weight (MW) were studied. The optimized co-polymer was further modified with glycidyl methacrylate (GM) and formulated with water, acrylic acid and Fuji II LC filler to form photo-cured cement. The effects of MW, GM tethering ratio, polymer liquid ratio and glass filler powder/polymer liquid (P/L) ratio were investigated. CS, flexural strength (FS) and viscosity were used as screening tools to find the optimal formulation. All the specimens were conditioned in distilled water at 37 degrees C for either 24 h or 7 days prior to testing. The results show that amino-acid-constructed polyalkenoic acids can be formed only from amino acid methacrylate derivatives or by co-polymerization of methacrylate with acrylate derivatives. Among the numerous co-polymers synthesized, poly(methacryloyl glutamic acid-co-acryloyl beta-alanine) or poly(MGA-co-ABA) with the molar ratio of 8:2 and MW of 19.5 kg/mol contributed the highest mechanical strengths and lower working viscosity to the cement. For photo-cured system, the effects of GM tethering ratio, polymer content and P/L ratio were significant. It is found that an appropriate ratio balance between these parameters is very important. The effect of molecular weight was not significant. The self-cured experimental cement was 32% higher in FS than Fuji II and the same in CS and DTS as Fuji II. The photo-cured experimental cement was 19%, 47% and 176% higher in CS, DTS and FS than Fuji II LC. |
| | |
Authors:
|
Dong Xie; Jong-Gu Park; Mona Faddah; Jun Zhao |
Related Documents
:
|
12880697 - Synthesis and antitumor activity of novel thermosensitive platinum(ii)-cyclotriphosphaz... 19142257 - Surface roughness and enamel loss with two microabrasion techniques. 15814247 - Preparation of a pla-peg block copolymer using a pla derivative with a formyl terminal ... 19732947 - Evaluation of bacteria-induced enamel demineralization using optical profilometry. 12801717 - Structure of the o-polysaccharide of proteus vulgaris o44: a new o-antigen that contain... 9736157 - Carbon source utilisation by bordetella bronchiseptica. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Journal of biomaterials science. Polymer edition Volume: 17 ISSN: 0920-5063 ISO Abbreviation: J Biomater Sci Polym Ed Publication Date: 2006 |
Date Detail:
|
Created Date: 2006-05-12 Completed Date: 2006-07-20 Revised Date: 2008-02-20 |
Medline Journal Info:
|
Nlm Unique ID: 9007393 Medline TA: J Biomater Sci Polym Ed Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 303-22 Citation Subset: IM |
Affiliation:
|
Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University at Indianapolis, IN 46202, USA. dxie@iupui.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids
/
chemical synthesis,
chemistry* Biocompatible Materials / chemical synthesis, chemistry* Chemistry, Pharmaceutical Glass Ionomer Cements / chemical synthesis, chemistry* Magnetic Resonance Spectroscopy Methacrylates / chemical synthesis, chemistry* Polymers / chemistry* Tensile Strength |
| Grant Support | |
ID/Acronym/Agency:
|
1R01 EB03162-01/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 0/Biocompatible Materials; 0/Glass Ionomer Cements; 0/Methacrylates; 0/Polymers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Initiator structure influence on thermal and rheological properties of oligo(epsilon-caprolactone).
Next Document: Synthesis and characterization of poly(ethylene glycol)-poly(D,L-lactide-co-glycolide) poly(ethylene...