| Preparation and evaluation of radiopaque hydrogel microspheres based on PHEMA/iothalamic acid and PHEMA/iopanoic acid as particulate emboli. | |
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MedLine Citation:
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PMID: 2394768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Highly porous poly(2-hydroxyethyl methacrylate) (PHEMA) microspheres prepared by suspension polymerization of 2-hydroxyethyl methacrylate (HEMA) in presence of polymeric diluents such as poly(methyl methacrylate) (PMMA) in toluene and poly(tetramethylene glycol) (PTMG) were made radiopaque by esterification of the reactive hydroxyl groups with iothalamic acid and iopanoic acid, two radiopaque substances clinically used. Of the various solvents and catalysts examined, tetrahydrofuran (THF) and N,N'-dimethyl paratoluidine (DMPT) were found to be best for obtaining a high degree of conversion. More than 30 wt% iodine could be bound to the microspheres which made them sufficiently radiopaque to be imaged radiographically. Microspheres retained their porosity, swelling ability, hydrophilicity, and surface morphology to a significant extent after iodination. Preliminary implantation studies of such microspheres subcutaneously in rats have shown no adverse tissue reactions over a 6-month period. It is suggested that these microspheres would prove to be useful as particulate emboli in endovascular embolization. |
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Authors:
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A Jayakrishnan; B C Thanoo; K Rathinam; M Mohanty |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biomedical materials research Volume: 24 ISSN: 0021-9304 ISO Abbreviation: J. Biomed. Mater. Res. Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-10-09 Completed Date: 1990-10-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0112726 Medline TA: J Biomed Mater Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 993-1004 Citation Subset: IM |
Affiliation:
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Division of Polymer Chemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media Embolization, Therapeutic / methods* Evaluation Studies as Topic Gels Iopanoic Acid Iothalamic Acid Materials Testing Microscopy, Electron Microspheres* Polyhydroxyethyl Methacrylate Rats Rats, Inbred Strains Surface Properties |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Gels; 2276-90-6/Iothalamic Acid; 25249-16-5/Polyhydroxyethyl Methacrylate; 96-83-3/Iopanoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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