Document Detail

Preparation and evaluation of 99mTc(CO)3-labeled pentadecanoic acid derivative and its suspension in lipiodol.
MedLine Citation:
PMID:  19694585     Owner:  NLM     Status:  MEDLINE    
Abstract Transarterial embolization by the intra-arterial administration of 131I-lipiodol is a modality used in the treatment of liver cancer. Long-chain fatty acids, being highly lipophilic, are also known to localize in the liver, thus constituting favorable vectors for this modality of treatment. Toward this, we envisaged the derivatization of 15-bromopentadecanoic acid, rendering it suitable for incorporation of a tridentate chelating moiety, for radiolabeling with the [99mTc(CO)3(H2O)3]+ precursor. The complex prepared, being lipophilic, was expected to behave as a lipiodol surrogate. The radiolabeled complex could be obtained in >95% radiochemical yield, as characterized by high-performance liquid chromatography. The intravenous injection of the radiolabeled complex in mice resulted in 23.5% +/- 4.3% uptake of injected dose (ID) organ in the liver at 3 hours postinjection. However, the uptake of the lipiodol suspension of the complex at 3 hours postinjection in the liver was found to be 43.8 +/- 13.4% ID/organ, when injected via the portal vein.
Drishty Satpati; Usha Pandey; H D Sarma; Meera Venkatesh; Sharmila Banerjee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer biotherapy & radiopharmaceuticals     Volume:  24     ISSN:  1557-8852     ISO Abbreviation:  Cancer Biother. Radiopharm.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9605408     Medline TA:  Cancer Biother Radiopharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  503-7     Citation Subset:  IM    
Radiopharmaceuticals Division, Bhabha Atomic Research Center, Mumbai, India.
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MeSH Terms
Fatty Acids / chemistry,  pharmacokinetics
Iodine Radioisotopes / chemistry,  diagnostic use
Iodized Oil / chemistry*,  pharmacokinetics
Liver / metabolism
Radiopharmaceuticals / chemistry*,  pharmacokinetics
Rats, Wistar
Technetium Compounds / chemistry*,  pharmacokinetics
Tissue Distribution
Reg. No./Substance:
0/Fatty Acids; 0/Iodine Radioisotopes; 0/Radiopharmaceuticals; 0/Technetium Compounds; 0/pentadecanoic acid; 8001-40-9/Iodized Oil

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