Document Detail

Preparation of disodium fluorescein powders in association with lauric and capric acids.
MedLine Citation:
PMID:  14603518     Owner:  NLM     Status:  MEDLINE    
In previous studies micronized disodium fluorescein (DF) powders were coated with lauric or capric acid. This was a precursor to evaluating the effects of the fatty acids on the hygroscopic growth of the DF aerosols. Studies of the association of fatty acids with DF reflected a limited interpretation of the data obtained. The present study examines more closely the phenomena involved in coating the DF. It is concluded that lateral interactions due to the hydrophobic aliphatic tails of the fatty acids give rise to adsorption, aggregation, and flocculation, all of which cause inflections in the association isotherm rendering it nonlinear.
D J Cooney; A J Hickey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  92     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-06     Completed Date:  2004-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2341-4     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 92:2341-2344, 2003
Department of Biomedical Engineering, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
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MeSH Terms
Chromatography, Gas
Decanoic Acids / chemistry*
Drug Compounding
Fluorescein / chemistry*
Lauric Acids / chemistry*
Reference Standards
Surface-Active Agents / chemistry*
Reg. No./Substance:
0/Decanoic Acids; 0/Lauric Acids; 0/Powders; 0/Surface-Active Agents; 2321-07-5/Fluorescein

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