| Preparation of dehydro-L-ascorbic acid dimer by air oxidation of L-ascorbic acid in the presence of catalytic amounts of copper(II) acetate and pyridine. | |
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MedLine Citation:
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PMID: 15639252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The catalytic system Cu(AcO)2-pyridine 1:4 mol% in methanol, slowly catalyses the air oxidation of ascorbic acid to the 2-methyl hemi-ketal of dehydroascorbic acid 5, and hydrogen peroxide. However, with Cu(AcO)2-pyridine 3:4 mol% the air oxidation is quite fast and no hydrogen peroxide is present at the end of the reaction. Removal of the catalyst and refluxing the foamy 5 in MeCN gives the oxidized, dimeric, dehydroascorbic acid in very good yields (approximately 70%) contaminated by approximately 1-2% MeCN. |
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Authors:
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Eleftheria K Koliou; Panayiotis V Ioannou |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Carbohydrate research Volume: 340 ISSN: 0008-6215 ISO Abbreviation: Carbohydr. Res. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-10 Completed Date: 2005-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0043535 Medline TA: Carbohydr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 315-8 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Patras, GRC-26500 Patras, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ascorbic Acid
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analogs & derivatives,
chemistry* Catalysis Crystallization Dehydroascorbic Acid / chemical synthesis*, chemistry* Dimerization Molecular Structure Organometallic Compounds / chemistry* Oxidation-Reduction Pyridines / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Organometallic Compounds; 0/Pyridines; 110-86-1/pyridine; 142-71-2/cupric acetate; 490-83-5/Dehydroascorbic Acid; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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