| Preparation of chitosan-copper complexes and their antitumor activity. | |
| | |
MedLine Citation:
|
PMID: 16735119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Copper complexes of chitosan have been synthesized. Complexes with different copper to chitosan ratios were tested in vitro as potential antitumor agents with 293 cells and HeLa cells. At the ratio of 0.11 mol copper per one chitosan residue, the complex exhibited a higher antitumor activity and less toxicity than other copper-chitosan complexes tested. In addition, this study showed that copper-chitosan complex inhibited tumor cell proliferation by arresting the cell cycle progression at the S phase in 293 cells. |
| | |
Authors:
|
Yong Zheng; Ying Yi; Yipeng Qi; Yuting Wang; Weian Zhang; Ming Du |
Related Documents
:
|
20869539 - Correlative time-lapse imaging and electron microscopy to study abscission in hela cells. 18694939 - Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. 8922269 - Inhibition of colony formation of hela cells by naturally occurring and synthetic agents. 8918459 - The yopb protein of yersinia pseudotuberculosis is essential for the translocation of y... 17956629 - Single-walled carbon nanotube interactions with hela cells. 16044419 - Biological and chemical inhibitors of nf-kappab sensitize siha cells to cisplatin-induc... 173529 - Aldosterone production by isolated adrenal glomerulosa cells: stimulation by physiologi... 20156499 - Nanomaterials for in situ cell delivery and tissue regeneration. 21658409 - Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is... |
Publication Detail:
|
Type: Journal Article Date: 2006-06-02 |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: 16 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-06-20 Completed Date: 2006-09-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
|
Languages: eng Pagination: 4127-9 Citation Subset: IM |
Affiliation:
|
National Key Laboratory of Virology, School of Life Science, Wuhan University, and Hubei Zhongshan Hospital Pharmacy Department, Wuhan, Hubei, PR China. zhengxiaoyong@sina.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antineoplastic Agents
/
chemical synthesis*,
pharmacology* Cell Line, Tumor Chitosan / chemical synthesis, chemistry*, pharmacology Copper / chemistry*, pharmacology Humans |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 7440-50-8/Copper; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinester...
Next Document: m-Carborane bisphenol structure as a pharmacophore for selective estrogen receptor modulators.