Document Detail

Preparation of chitosan-copper complexes and their antitumor activity.
MedLine Citation:
PMID:  16735119     Owner:  NLM     Status:  MEDLINE    
Copper complexes of chitosan have been synthesized. Complexes with different copper to chitosan ratios were tested in vitro as potential antitumor agents with 293 cells and HeLa cells. At the ratio of 0.11 mol copper per one chitosan residue, the complex exhibited a higher antitumor activity and less toxicity than other copper-chitosan complexes tested. In addition, this study showed that copper-chitosan complex inhibited tumor cell proliferation by arresting the cell cycle progression at the S phase in 293 cells.
Yong Zheng; Ying Yi; Yipeng Qi; Yuting Wang; Weian Zhang; Ming Du
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Publication Detail:
Type:  Journal Article     Date:  2006-06-02
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  16     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-06-20     Completed Date:  2006-09-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  4127-9     Citation Subset:  IM    
National Key Laboratory of Virology, School of Life Science, Wuhan University, and Hubei Zhongshan Hospital Pharmacy Department, Wuhan, Hubei, PR China.
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MeSH Terms
Antineoplastic Agents / chemical synthesis*,  pharmacology*
Cell Line, Tumor
Chitosan / chemical synthesis,  chemistry*,  pharmacology
Copper / chemistry*,  pharmacology
Reg. No./Substance:
0/Antineoplastic Agents; 7440-50-8/Copper; 9012-76-4/Chitosan

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