| Preparation and characterization of paclitaxel delivery system based on semi-solid lipid nanoparticles coated with poly (ethylene glycol). | |
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MedLine Citation:
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PMID: 20662317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The current formulation of paclitaxel causes significant side effects, so there is a need to develop a safer delivery system. In this study, novel semi-solid lipid nanoparticles (PEG-PE-SSLN) were prepared, and evaluated as delivery vehicles for paclitaxel. The PEG-PE-SSLN are approximately 213 nm in size with a zeta-potential of -37 mV, compared to Span60-SSLN with a particle size of over 275 nm and zeta-potential of -29 mV. The encapsulation efficiency of PEG-PE-SSLN could be as high as 98%. Furthermore, differential scanning calorimetry (DSC) analysis indicated that paclitaxel in the nanoparticles existed in an amorphous form. A sustained release of 85% of the loaded paclitaxel from PEG-PE-SSLN within 12 days was observed while release from Span60-SSLN particles was complete within 6 days. PEG-PE-SSLN can effectively decrease phagocytosis of murine peritoneal macrophages. Lyopholization of SSLNs in the presence of trehalose tended to preserve their stability. Therefore, PEG-PE-SSLN represents an improved and promising paclitaxel delivery system. |
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Authors:
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Lifang Wu; Cui Tang; Chunhua Yin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 65 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-09-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 493-9 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University Shanghai, PR China. wlfang2008@sina.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Phytogenic / administration & dosage*, pharmacokinetics Calorimetry, Differential Scanning Chromatography, High Pressure Liquid Drug Compounding Drug Delivery Systems Injections, Intravenous Lipids Macrophages, Peritoneal / metabolism Mice Microscopy, Electron, Transmission Nanoparticles Paclitaxel / administration & dosage*, pharmacokinetics Particle Size Phagocytosis Pharmaceutic Aids Polyethylene Glycols Solubility Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Lipids; 0/Pharmaceutic Aids; 0/Polyethylene Glycols; 33069-62-4/Paclitaxel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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