Document Detail

Preparation and characterization of medium-chain fatty acid liposomes by lyophilization.
MedLine Citation:
PMID:  19848446     Owner:  NLM     Status:  MEDLINE    
In this study, medium-chain fatty acid (MCFA) liposomes were prepared by the film ultrasonic dispersion, modified ethanol injection, and reverse-phase evaporate methods. The results indicated that the liposomes prepared by the thin-film ultrasonic dispersion method had a high entrapment efficiency of 82.7% and a good distribution in size diameters. The MCFA liposomes were freeze-dried and the optimal preparation conditions of freeze-drying were as follows: The cryoprotectants were mannitol and sucrose (1:1 w/w), the hydrated medium was distilled water, and the freeze-drying time was 48 hours. Under these conditions, the freeze-dried MCFA liposomes had a perfect appearance, a small particle size, and high encapsulation efficiency. The mean diameters were 251.1 and 265.3 nm, and the encapsulation efficiencies were 80.5 and 79.2% for freshly prepared and reconstituted liposomes, respectively.
Chengmei Liu; Shuibing Yang; Wei Liu; Ruilian Wang; Jie Wan; Weilin Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of liposome research     Volume:  20     ISSN:  1532-2394     ISO Abbreviation:  J Liposome Res     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001952     Medline TA:  J Liposome Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  183-90     Citation Subset:  IM    
State Key Laboratory of Food Science and Technology, Department of Life Science and Food Engineering, Nanchang University, Nanchang, China.
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MeSH Terms
Decanoic Acids / chemistry
Freeze Drying / methods
Liposomes / chemical synthesis*,  chemistry
Microscopy, Electron, Transmission
Octanoic Acids / chemistry
Physicochemical Phenomena
Reg. No./Substance:
0/Decanoic Acids; 0/Liposomes; 0/Octanoic Acids

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