Document Detail

Preparation and characterization of iron-containing liposomes: their effect on soluble iron uptake by Caco-2 cells.
MedLine Citation:
PMID:  20854064     Owner:  NLM     Status:  In-Data-Review    
The aim of this work was to study the iron uptake of Caco-2 cells incubated with five different formulations of liposomes containing iron. The vesicles were also characterized before, during, and after in vitro digestion. Caco-2 cells were incubated with digested and nondigested liposomes, and soluble iron uptake was determined. Nondigested liposomes made with chitosan (CHI) or the cationic lipid, DC-Cholesterol (DC-CHOL), generated the highest iron uptake. However, these two formulations were highly unstable under in vitro digestion, resulting in nonmeasurable iron uptake. Digested conventional liposomes composed of soybean phosphatidylcholine (SPC), hydrogentated phosphatidylcholine (HSPC), or HSPC and cholesterol (CHOL) presented the highest iron-uptake values. These liposomal formulations protected iron from oxidation and improved iron uptake from intestinal cells, compared to an aqueous solution of ferrous sulphate.
Laura G Hermida; Anna Roig; Carlos Bregni; Manuel Sabés-Xamaní; Ramon Barnadas-Rodríguez
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Publication Detail:
Type:  Journal Article     Date:  2010-09-20
Journal Detail:
Title:  Journal of liposome research     Volume:  21     ISSN:  1532-2394     ISO Abbreviation:  J Liposome Res     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001952     Medline TA:  J Liposome Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-12     Citation Subset:  IM    
Center of Research and Development in Chemistry, National Institute of Industrial Technology (INTI), Buenos Aires, Argentina.
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