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Preparation, characterization and in vitro testing of poly(lactic-co-glycolic) acid/barium titanate nanoparticle composites for enhanced cellular proliferation.
MedLine Citation:
PMID:  20981490     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The recent advancements in tissue engineering and, more in general, in cell-based applications, has led to an ever increasing interest toward new materials for sustained cell proliferation and differentiation. Here, the preparation and the characterization of scaffolds based on poly(lactic-co-glycolic) acid / barium titanate nanoparticle composites are presented. In vitro testing on H9C2 cell line demonstrates how the presence of the nanoparticles positively affects both the proliferation and the differentiation of this muscle-like cell line. Finally, the possibility to obtain porous scaffold and, therefore, an actual 3D culture system, is introduced.
Authors:
Gianni Ciofani; Leonardo Ricotti; Virgilio Mattoli
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedical microdevices     Volume:  13     ISSN:  1572-8781     ISO Abbreviation:  Biomed Microdevices     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887374     Medline TA:  Biomed Microdevices     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255-66     Citation Subset:  IM    
Affiliation:
Italian Institute of Technology, Smart Materials Lab, Center for Micro-BioRobotics c/o Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy, g.ciofani@sssup.it.
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