| Preparation, characterization and cytotoxicity of carbon nanotube-chitosan-phycocyanin complex. | |
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MedLine Citation:
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PMID: 22173212 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Photodynamic therapy (PDT) or photothermal therapy (PTT) using nanomaterials has shown great prospect for cancer treatment. Phycocyanin (PC) is a photoharvesting pigment and is also an attractive candidate for PDT. The multiwalled carbon nanotube (MWNT) is a potent candidate for PTT due to its extraordinary photo-to-thermal energy conversion efficiency upon excitation with near-infrared (NIR) light. To date, although MWNT-CS complexes have been well studied, no report about the reconjugation of MWNT-CS with phycocyanin is available in the literature. Here, by using water-soluble chitosan (CS), we prepared and characterized a novel biomaterial, MWNT-CS-PC, with the potential for PDT and PTT. The cytotoxicity experiments found that MWNT-CS-PC exhibited cell growth inhibition activity. Moreover, with irradiation of NIR light (808 nm) or visible light (532 nm), the photoinduced cytotoxicity was indeed enhanced. These results suggest that MWNT-CS-PC may potentially serve as a future photodynamic and photothermal therapy for cancer. |
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Authors:
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Xiaoxia Liao; Xuewu Zhang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-16 |
Journal Detail:
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Title: Nanotechnology Volume: 23 ISSN: 1361-6528 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101241272 Medline TA: Nanotechnology Country: - |
Other Details:
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Languages: ENG Pagination: 035101 Citation Subset: - |
Affiliation:
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College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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