Document Detail

Preparation, characterization, cellular uptake and evaluation in vivo of solid lipid nanoparticles loaded with cucurbitacin B.
MedLine Citation:
PMID:  22794139     Owner:  NLM     Status:  Publisher    
In this work, solid lipid nanoparticles loaded with cucurbitacin B (Cu B-SLNs) were prepared. It was found that the concentration of poloxamer 188 and soybean lecithin had effects on the mean particle size and size distribution. The zeta potentials were around -33 mV. In vitro release studies showed a sustained release after a burst release. Internalization of Cu B into HepG2 cells could be enhanced by the encapsulation of SLN matrix. The IC50 values of Cu B-SLNs were lower than that of Cu B solution. Both free Cu B and Cu B-SLNs had effectively inhibited the tumor growth and displayed a dose-dependent anti-tumor efficacy. Cu B-SLNs at a dose of 0.11 mg/kg produced the greatest anti-tumor effects (53.3%), which was significant higher than Cu B solution (31.5%, p < 0.05). Cu B-SLNs showed a longer MRT in vivo. The AUC of Cu B-SLNs for tumor increased 3.5 -fold when compared to Cu B solution. The targeting efficiency of Cu B-SLNs was 1.94 times higher in liver as compared to that of Cu B solution. These results indicated that Cu-B SLNs could passively target the tumor with EPR effect, improve the therapeutic efficacy of Cu B, and reduce the doses.
Haiyang Hu; Dan Liu; Xiuli Zhao; Mingxi Qiao; Dawei Chen
Related Documents :
17121919 - Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic...
25162999 - Preclinical activity of multiple-target gold(iii)-dithiocarbamato peptidomimetics in pr...
18471519 - Knockdown of rna binding protein musashi-1 leads to tumor regression in vivo.
21559269 - Delineation of chondroid lipoma: an immunohistochemical and molecular biological analysis.
18053639 - Low hmlh1 expression prior to definitive chemoradiotherapy predicts poor prognosis in e...
9546379 - Cooperative interactions between rb and p53 regulate cell proliferation, cell senescenc...
7954339 - Constitutive expression of the heat shock protein 72 kda in human melanoma cells.
12907619 - Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.
7907889 - Carcinoid syndrome.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-16
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  -     ISSN:  1520-5762     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
School of Pharmacy, Shenyang Pharmaceutical University , Shenyang, Liaoning Province , China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dietary (Poly)phenolics in Human Health: Structures, Bioavailability and Evidence of Protective Effe...
Next Document:  Asylum-Seekers' Experiences of Trauma-Focused Cognitive Behaviour Therapy for Post-Traumatic Stress ...