Document Detail

Preparation and characterization of acid dehydration products of aflatoxicol.
MedLine Citation:
PMID:  6826516     Owner:  NLM     Status:  MEDLINE    
Treatment of aflatoxicol with acid resulted in the formation of dehydrated derivatives with the 2,3 double bond either hydrated or unaffected. Chromatographic and physicochemical analyses of the purified derivatives revealed that hydration of the 2,3 double bond of aflatoxicol with simultaneous dehydration occurred when sulfuric acid was used. When a weaker acid such as chloroacetic acid was used, no hydration occurred, and 2 isomeric forms of the dehydrated aflatoxicol were obtained. Chicken embryo assay and the Ames test revealed that dehydrated aflatoxicols were much less toxic and mutagenic than aflatoxicol. A mechanism for the dehydration of aflatoxicol is proposed.
H P Lau; F S Chu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal - Association of Official Analytical Chemists     Volume:  66     ISSN:  0004-5756     ISO Abbreviation:  J Assoc Off Anal Chem     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7505559     Medline TA:  J Assoc Off Anal Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-101     Citation Subset:  IM    
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MeSH Terms
Aflatoxins* / analysis,  toxicity
Chemical Phenomena
Chick Embryo
Food Analysis
Mutagenicity Tests
Grant Support
Reg. No./Substance:
0/Aflatoxins; 29611-03-8/aflatoxicol

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