| Preparation and biological activity of some aminoacyl and peptidyl derivatives of 2'-amino-2'-deoxyuridine. | |
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MedLine Citation:
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PMID: 1099204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several aminoacyl and peptidyl derivatives of 2'-amino-2'-deoxyuridine have been synthesized. 2'-Amino-2'-deoxyuridine (I) and 2'-N-glycyl-2'-amino-2'-deoxyuridine (IIIa) were condensed with N-Cbz blocked p-nitrophenyl esters of the appropriate amino acids to afford the protected aminoacyl and peptidyl nucleosides. Removal of the protecting groups gave the title compounds in good yields. The biological effects of these derivatives are discussed. |
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Authors:
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R A Sharma; M Bobek; A Bloch |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 18 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 1975 Sep |
Date Detail:
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Created Date: 1975-11-22 Completed Date: 1975-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 955-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Deoxyuridine
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analogs & derivatives*,
chemical synthesis,
pharmacology Escherichia coli / drug effects Microbial Sensitivity Tests Peptides / chemical synthesis, pharmacology Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 951-78-0/Deoxyuridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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