| Preparation and biodisposition of methoxypolyethylene glycol amine-poly(DL-lactic acid) copolymer nanoparticles loaded with pyrene-ended poly(DL-lactic acid). | |
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MedLine Citation:
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PMID: 18448290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A formyl group-ended poly(DL-lactic acid) (PLA-aldehyde), synthesized in the same manner as reported previously, was utilized to produce the polymeric marker for PLA-related nanoparticles. Namely, pyrene-ended poly(DL-lactic acid) (PLA-pyrene) was prepared as a polymeric marker by the reductive amination of PLA-aldehyde and aminopyrene. Methoxypolyethylene glycol amine-poly(DL-lactic acid) block copolymer (PLA-(MeO-PEG) nanoparticles loaded with PLA-pyrene were prepared, and examined on retention of PLA-pyrene in the nanoparticles, and biodisposition in normal and sarcoma-180 solid tumor-bearing mice. PLA-pyrene was retained stably in PLA-(MeO-PEG) nanoparticles in a PBS-ethanol (7:3, v/v) mixture and a plasma-PBS (1:1, v/v) mixture, indicating that PLA-pyrene might be a useful marker of PLA-(MeO-PEG) nanoparticles themselves. After i.v. injection in normal rats, the plasma level of PLA-pyrene was very high for initial 8h, and accumulated gradually into organs, especially spleen and liver. After i.v. injection in tumor-bearing mice, similar biodistribution profiles of PLA-pyrene were observed, and PLA-pyrene was accumulated well in tumor, suggesting that PLA-(MeO-PEG) nanoparticles should be delivered efficiently to solid tumors. It is suggested that PLA-pyrene might be a useful probe of the nanoparticles themselves. In addition, it was demonstrated that PLA-(MeO-PEG) nanoparticles should be a useful drug carrier for passive tumor targeting. |
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Authors:
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Masanaho Sasatsu; Hiraku Onishi; Yoshiharu Machida |
Publication Detail:
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Type: Journal Article Date: 2008-03-18 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 358 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-03 Completed Date: 2008-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 271-7 Citation Subset: IM |
Affiliation:
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Department of Drug Delivery Research, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, Gel Fluorescent Dyes Indicators and Reagents Injections, Intravenous Lactic Acid / chemical synthesis, chemistry*, pharmacokinetics Magnetic Resonance Spectroscopy Male Mice Microscopy, Electron, Transmission Nanoparticles / chemistry* Particle Size Polyethylene Glycols / chemical synthesis, chemistry*, pharmacokinetics Polymers / chemical synthesis, chemistry*, pharmacokinetics Pyrenes / chemical synthesis, chemistry*, pharmacokinetics Sarcoma 180 / metabolism Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Fluorescent Dyes; 0/Indicators and Reagents; 0/Polyethylene Glycols; 0/Polymers; 0/Pyrenes; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid; 9004-74-4/monomethoxypolyethylene glycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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