| Preparation of biodegradable networks by photo-crosslinking lactide, epsilon-caprolactone and trimethylene carbonate-based oligomers functionalized with fumaric acid monoethyl ester. | |
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MedLine Citation:
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PMID: 15603775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biodegradable polymer networks were prepared from fumaric acid derivatives of oligomeric esters. Photo-crosslinkable macromers were prepared by reacting star-shaped hydroxyl-group terminated lactide, epsilon-caprolactone and trimethylene carbonate based oligomers and fumaric acid monoethyl ester in the presence of N,N-dicyclohexylcarbodiimide and 4-dimethylamino pyridine at room temperature. The functionalization method is facile and suited for many hydroxyl-terminated oligomers. The reactivity of the fumarate end groups is such that, upon crosslinking by UV radical polymerization, networks with high gel contents (up to 96%) can be obtained without the addition of reactive diluents. The physical properties of the networks can be tuned by adjusting the composition, architecture and molecular weight of the oligomeric precursors. Such networks, built up of non-toxic compounds and designed to release benign degradation products, may find wide application in tissue engineering and other areas of biomedical research. |
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Authors:
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Dirk W Grijpma; Qingpu Hou; Jan Feijen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomaterials Volume: 26 ISSN: 0142-9612 ISO Abbreviation: Biomaterials Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2004-12-17 Completed Date: 2005-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
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Languages: eng Pagination: 2795-802 Citation Subset: IM |
Affiliation:
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Faculty of Science and Technology, Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology (BMTI), University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands. d.w.grijpma@utwente.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminopyridine
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analogs & derivatives*,
chemistry Biocompatible Materials / chemistry* Biodegradation, Environmental Cross-Linking Reagents / pharmacology* Dicyclohexylcarbodiimide / chemistry Dioxanes / chemistry* Free Radicals Fumarates / chemistry* Glass / chemistry Hexanoic Acids / chemistry* Lactones / chemistry* Light Macromolecular Substances / chemistry Magnetic Resonance Spectroscopy Microscopy, Electron, Scanning Models, Chemical Polyesters / chemistry* Polymers / chemistry Temperature Tensile Strength Tissue Engineering / methods Ultraviolet Rays |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Cross-Linking Reagents; 0/Dioxanes; 0/Free Radicals; 0/Fumarates; 0/Hexanoic Acids; 0/Lactones; 0/Macromolecular Substances; 0/Polyesters; 0/Polymers; 0/trimethylene carbonate; 1122-58-3/4-dimethylaminopyridine; 2459-05-4/ethyl fumarate; 26969-66-4/poly(lactide); 502-44-3/caprolactone; 504-24-5/4-Aminopyridine; 538-75-0/Dicyclohexylcarbodiimide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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