Document Detail

Preparation of biodegradable networks by photo-crosslinking lactide, epsilon-caprolactone and trimethylene carbonate-based oligomers functionalized with fumaric acid monoethyl ester.
MedLine Citation:
PMID:  15603775     Owner:  NLM     Status:  MEDLINE    
Biodegradable polymer networks were prepared from fumaric acid derivatives of oligomeric esters. Photo-crosslinkable macromers were prepared by reacting star-shaped hydroxyl-group terminated lactide, epsilon-caprolactone and trimethylene carbonate based oligomers and fumaric acid monoethyl ester in the presence of N,N-dicyclohexylcarbodiimide and 4-dimethylamino pyridine at room temperature. The functionalization method is facile and suited for many hydroxyl-terminated oligomers. The reactivity of the fumarate end groups is such that, upon crosslinking by UV radical polymerization, networks with high gel contents (up to 96%) can be obtained without the addition of reactive diluents. The physical properties of the networks can be tuned by adjusting the composition, architecture and molecular weight of the oligomeric precursors. Such networks, built up of non-toxic compounds and designed to release benign degradation products, may find wide application in tissue engineering and other areas of biomedical research.
Dirk W Grijpma; Qingpu Hou; Jan Feijen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomaterials     Volume:  26     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2004-12-17     Completed Date:  2005-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  2795-802     Citation Subset:  IM    
Faculty of Science and Technology, Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology (BMTI), University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
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MeSH Terms
4-Aminopyridine / analogs & derivatives*,  chemistry
Biocompatible Materials / chemistry*
Biodegradation, Environmental
Cross-Linking Reagents / pharmacology*
Dicyclohexylcarbodiimide / chemistry
Dioxanes / chemistry*
Free Radicals
Fumarates / chemistry*
Glass / chemistry
Hexanoic Acids / chemistry*
Lactones / chemistry*
Macromolecular Substances / chemistry
Magnetic Resonance Spectroscopy
Microscopy, Electron, Scanning
Models, Chemical
Polyesters / chemistry*
Polymers / chemistry
Tensile Strength
Tissue Engineering / methods
Ultraviolet Rays
Reg. No./Substance:
0/Biocompatible Materials; 0/Cross-Linking Reagents; 0/Dioxanes; 0/Free Radicals; 0/Fumarates; 0/Hexanoic Acids; 0/Lactones; 0/Macromolecular Substances; 0/Polyesters; 0/Polymers; 0/trimethylene carbonate; 1122-58-3/4-dimethylaminopyridine; 2459-05-4/ethyl fumarate; 26969-66-4/poly(lactide); 502-44-3/caprolactone; 504-24-5/4-Aminopyridine; 538-75-0/Dicyclohexylcarbodiimide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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