| Preparation of N,O-carboxymethyl chitosan nanoparticles as an insulin carrier. | |
| | |
MedLine Citation:
|
PMID: 19839790 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The aim of this research was to develop pH-sensitive insulin-loaded NOCC (N,O-carboxymethyl chitosan) nanoparticles for the controlled release of insulin via the oral route. Thus, in this study, insulin-loaded NOCC nanoparticles were prepared by ionic gelation of NOCC with TPP (tripolyphosphate). NOCC nanoparticles were formed at conditions of 2 mg/ml of NOCC and 1 mg/ml of TPP. It was found that the encapsulation efficiency and process yield decreased with increasing NOCC to TPP weight ratio. Furthermore, the cumulative release of insulin from insulin-loaded NOCC nanoparticles decreased with decreasing NOCC-to-TPP weight ratio, but it increased with decreasing the initial concentration of insulin. The higher the pH of the phosphate buffered saline, the greater the amount of cumulative release of insulin-loaded NOCC nanoparticles, and thus they could protect insulin from acid. |
| | |
Authors:
|
Chuen-Chang Lin; Cheng-Wei Lin |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Drug delivery Volume: 16 ISSN: 1521-0464 ISO Abbreviation: Drug Deliv Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9417471 Medline TA: Drug Deliv Country: England |
Other Details:
|
Languages: eng Pagination: 458-64 Citation Subset: IM |
Affiliation:
|
Department of Chemical & Materials Engineering, National Yunlin University of Science and Technology, Douliu, Yunlin, Taiwan. linchuen@yuntech.edu.tw |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Formulation and in vitro evaluation of a PEGylated microscopic lipospheres delivery system for ceftr...
Next Document: Biodegradable alginate microparticles developed by electrohydrodynamic spraying techniques for oral ...