Document Detail

Preparation of the Dräger Fabius GS workstation for malignant hyperthermia-susceptible patients.
MedLine Citation:
PMID:  19399571     Owner:  NLM     Status:  MEDLINE    
PURPOSE: In order to establish guidelines for the preparation of the Dräger Fabius GS premium anesthetic workstation for malignant hyperthermia-susceptible patients, the authors evaluated the effect of the workstation's exchangeable and autoclavable components on the washout of isoflurane. METHODS: A Dräger Fabius GS workstation was primed with 1.5% isoflurane, and exchangeable components were replaced as follows: Group 1: no replacement (control); Group 2: autoclaved ventilator diaphragm and ventilator hose; Group 3: flushed ventilator diaphragm and ventilator hose; Group 4: autoclaved compact breathing system. The fresh gas flow (FGF) was set at 10 L . min(-1), and the concentration of isoflurane in the inspiratory limb of the circle breathing circuit was recorded every minute until an endpoint of 5.0 parts per million (ppm) was achieved, at which time the FGF was reduced to 3 L . min(-1). Six experiments were conducted in each of the four groups. RESULTS: The time to achieve an isoflurane concentration of 5.0 ppm decreased in the following order: Group 1 (151 +/- 17 min) > Group 3 (137 +/- 7 min) > Group 4 (122 +/- 11 min) > Group 2 (42 +/- 6 min) (P < 0.01 vs control). Isoflurane concentration increased approximately fivefold when the FGF was reduced to 3 L . min(-1). CONCLUSION: Anesthetic washout from the Dräger Fabius GS is relatively slow. Although washout was accelerated when the Dräger Fabius GS was equipped with autoclaved components, the reduction in washout time may be less than that required for this technique to be accepted into clinical practice. A dedicated vapor-free workstation may be preferable for rapid turnover between cases.
Robert J Whitty; Gail K Wong; Guy C Petroz; Carolyne Pehora; Mark W Crawford
Publication Detail:
Type:  Journal Article     Date:  2009-04-28
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  56     ISSN:  1496-8975     ISO Abbreviation:  Can J Anaesth     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-26     Completed Date:  2009-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  497-501     Citation Subset:  IM    
Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
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MeSH Terms
Anesthesia, Inhalation / instrumentation*
Anesthesiology / instrumentation
Anesthetics, Inhalation / administration & dosage*
Disease Susceptibility
Guidelines as Topic
Isoflurane / administration & dosage*
Malignant Hyperthermia / prevention & control*
Time Factors
Ventilators, Mechanical
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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