Document Detail


Preparation, Characterization, and in vivo Evaluation of Doxorubicin Loaded BSA Nanoparticles with Folic Acid Modified Dextran Surface.
MedLine Citation:
PMID:  23370437     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Biocompatible and biodegradable doxorubicin loaded nanoparticles with targeting ability were prepared from BSA-dextran-folic acid conjugate via a pH adjustment and heating process. The BSA-dextran-folic acid conjugate was produced by an esterification reaction between folic acid and dextran and then the Maillard reaction between the modified dextran and BSA. The nanoparticles have a size about 90nm and excellent dispersibility at pH 7.4 aqueous solution. The doxorubicin loading efficiency and loading amount of the nanoparticles are larger than 90% and 14%, respectively. The antitumor activity and toxicity of the nanoparticles were evaluated through murine ascites hepatoma H22 tumor-bearing mice. The nanoparticles allow the administration of the doxorubicin with higher dose. At doxorubicin dose of 10mg/kg, the nanoparticles can achieve 88.9% of the tumor inhibition rate that is the same as the free doxorubicin at the dose of 5mg/kg. Importantly, the nanoparticles can decrease the toxicity of doxorubicin that results in a significant increase of the average life time in comparison with the free doxorubicin as well as the nanoparticles without folic acid.
Authors:
Hequn Hao; Qingming Ma; Chong Huang; Fen He; Ping Yao
Related Documents :
7191847 - A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isol...
23628087 - Alkyl caffeates as anti-helicobacter pylori and scavenger of oxidants produced by neutr...
24715497 - Retroconversion of docosapentaenoic acid (n-6): an alternative pathway for biosynthesis...
24023657 - Induction of porcine host defense peptide gene expression by short-chain fatty acids an...
10223627 - Concentration and dispersal of a pseudo-nitzschia bloom in penn cove, washington, usa.
8562787 - Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composit...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  -     ISSN:  1873-3476     ISO Abbreviation:  Int J Pharm     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-2-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
Affiliation:
State Key Laboratory of Molecular Engineering of Polymer and Department of Macromolecular Science, Fudan University, Shanghai 200433, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nanostructured Fluids from pluronic(®) Mixtures.
Next Document:  Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obst...