| Preparation of 2- and 4-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans having potent antagonistic activity against human leukotriene B4 BLT1 and/or BLT2 receptors. | |
| | |
MedLine Citation:
|
PMID: 15565232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
(E)-2-Acetyl-4-(2-diethylcarbamoyl-1-methylvinyl)-7-(1-phenylethoxy)benzo[b]furan (4b) with a characteristic conformation and (E)-2-(2-morpholinocarbo-1-methylvinyl)-7-ethoxycarbopropoxybenzo[b]furan ((E)-3b) were prepared and evaluated for their leukotriene B4(LTB4) antagonistic activity. Compound 4b showed potent antagonistic activity against human BLT1 and BLT2 receptors. Compound (E)-3b displayed selective BLT2 receptor antagonistic activity. Both compounds were inactive to cysteinyl LT receptors. |
| | |
Authors:
|
Kumiko Ando; Eriko Tsuji; Yuko Ando; Jun-ichi Kunitomo; Masayuki Yamashita; Shunsaku Ohta; Takeshi Nabe; Shigekatsu Kohno; Takehiko Yokomizo; Takao Shimizu; Yoshitaka Ohishi |
Publication Detail:
|
Type: Journal Article Date: 2004-11-01 |
Journal Detail:
|
Title: Organic & biomolecular chemistry Volume: 2 ISSN: 1477-0520 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2004 Dec |
Date Detail:
|
Created Date: 2004-11-26 Completed Date: 2005-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
|
Languages: eng Pagination: 3427-31 Citation Subset: IM |
Affiliation:
|
School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya, 663-8179, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Benzofurans / chemical synthesis*, chemistry, pharmacology* CHO Cells Calcium / metabolism Calcium Signaling / drug effects Carbamates / chemical synthesis*, chemistry, pharmacology* Cricetinae Crystallography, X-Ray Gene Expression Humans Inhibitory Concentration 50 Molecular Conformation Molecular Structure Morpholines / chemical synthesis*, chemistry, pharmacology* Receptors, Leukotriene B4 / antagonists & inhibitors*, genetics, metabolism Receptors, Purinergic P2 / antagonists & inhibitors*, genetics, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/2-(2-morpholinocarbo-1-methylvinyl)-7-ethoxycarbopropoxybenzo(b)furan; 0/2-acetyl-4-(2-diethylcarbamoyl-1-methylvinyl)-7-(1-phenylethoxy)benzo(b)furan; 0/Benzofurans; 0/Carbamates; 0/LTB4R protein, human; 0/LTB4R2 protein, human; 0/Morpholines; 0/Receptors, Leukotriene B4; 0/Receptors, Purinergic P2; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multivalency in supramolecular chemistry and nanofabrication.
Next Document: Self-replication vs. reactive binary complexes--manipulating recognition-mediated cycloadditions by ...