Document Detail


Preovulatory, postovulatory, and postmaternal recognition effects of concentrations of progesterone on embryonic survival in the cow.
MedLine Citation:
PMID:  15471804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although fertilization rate usually is very high when male fertility is normal, pregnancy rates are below expectations when defined by the birth of live offspring in response to first service. Factors that affect establishment and retention of pregnancy include 1) preovulatory influences on the follicle and oocyte, 2) early postovulatory uterine and luteal function, 3) concentrations of hormones associated with trophoblastic and endometrial function during maternal recognition of pregnancy, and 4) less-well understood factors during the peri-attachment period. For example, decreased progesterone during preovulatory follicular development leads to a persistent follicle, premature resumption of meiosis, and a high incidence of embryonic death between the 2- and 16-cell stages. Elevated PGF(2alpha) during d 4 to 9 of the estrous cycle not only caused luteolysis but also had a direct embryotoxic effect during the morula-to-blastocyst transition. Ideal conditions during placentation and attachment are not clearly defined. Late embryonic mortality might be increased after ovulation of persistent or immature follicles. Nominal increases in secretion of PGF(2alpha) between d 30 and 35 might be important for attachment and placentation. Lower survival of embryos from wk 5 to wk 7 to 9 of gestation in the cow was associated with lower circulating concentrations of progesterone on wk 5. To maximize embryonic survival in the cow, management must provide high progesterone before estrus, quality detection of estrus, and timely insemination. Luteolytic influences of estradiol-17beta or PGF(2alpha) must be minimized early after mating and during maternal recognition of pregnancy, and high progesterone is needed during the late embryonic/early fetal period.
Authors:
E K Inskeep
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Journal of animal science     Volume:  82 E-Suppl     ISSN:  1525-3163     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-08     Completed Date:  2006-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E24-39     Citation Subset:  IM    
Affiliation:
Division of Animal and Veterinary Sciences, West Virginia University, Morgantown 26506-6108, USA. einskeep@wvu.edu <einskeep@wvu.edu>
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle / blood,  embryology,  physiology*
Dinoprost / physiology
Embryo Loss / blood,  etiology,  veterinary*
Embryonic Development / physiology*
Estrogens / physiology,  secretion
Female
Fertility / physiology*
Lactation / blood,  physiology
Luteal Phase / blood,  physiology
Ovarian Follicle / physiology
Ovulation / blood,  physiology*
Pregnancy
Progesterone / blood*
Chemical
Reg. No./Substance:
0/Estrogens; 551-11-1/Dinoprost; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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