Document Detail

Preovulatory changes in follicular prostaglandins and their role in ovulation in cattle.
MedLine Citation:
PMID:  1586897     Owner:  NLM     Status:  MEDLINE    
Indomethacin (INDO, n = 5) or vehicle (CONTROL, n = 4) was injected into superovulated heifers at 48 and 60 h following a luteolytic cloprostenol injection (0 h). One heifer from each group was ovariectomized (OVX) at 48, 56, 64 and 72 h. The fifth heifer of the INDO group was OVX at 80 h. Blood samples were collected at 0 h, every 2 h between 37 and 47 h, and at the time of each OVX to monitor plasma progesterone (P4) and luteinizing hormone (LH) concentrations. Following each OVX, the number and size of follicles were recorded and the incidence of ovulation determined. Follicular fluid (FF) was aspirated from follicles greater than or equal to 8 mm to determine the concentration of prostaglandins E2 (PGE2) and F2 alpha (PGF2 alpha). The highest PG concentrations were measured in both groups at 24-25 h following the preovulatory LH surge and the PGF2 alpha concentration at this time was significantly greater (p less than 0.01) in the CONTROL group compared to the INDO group. By 35-36 h after the LH surge, 75% (25/34) of the CONTROL follicles had ovulated, whereas there were no ovulations (0/50) on either ovary of the INDO treated heifer. These preliminary results suggest that the preovulatory rise of PGs in FF, particularly PGF2 alpha, is essential for ovulation and that suppression of this rise with indomethacin will inhibit ovulation in heifers.
J E Algire; A Srikandakumar; L A Guilbault; B R Downey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire     Volume:  56     ISSN:  0830-9000     ISO Abbreviation:  Can. J. Vet. Res.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-06-25     Completed Date:  1992-06-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8607793     Medline TA:  Can J Vet Res     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  67-9     Citation Subset:  IM    
Department of Animal Science, McGill University, Ste. Anne de Bellevue, Québec.
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MeSH Terms
Cattle / physiology*
Cloprostenol / pharmacology
Dinoprost / physiology
Dinoprostone / physiology
Follicular Fluid / chemistry*
Indomethacin / pharmacology
Ovariectomy / veterinary
Ovary / physiology
Ovulation / physiology*
Prostaglandins / analysis,  physiology*
Random Allocation
Superovulation / physiology
Reg. No./Substance:
0/Prostaglandins; 363-24-6/Dinoprostone; 40665-92-7/Cloprostenol; 53-86-1/Indomethacin; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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