Document Detail


Preoptic and hypothalamic neurons and the initiation of locomotion in the anesthetized rat.
MedLine Citation:
PMID:  8105509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite its insensate condition and apparent motoric depression, the anesthetized rat can provide useful information about the systems involved in locomotor initiation. The preparation appears to be particularly appropriate for the study of the appetitive locomotor systems and may be more limited for the study of the circuits involved in exploratory and defensive locomotion. In the anesthetized rat, pharmacological evidence indicates that the preoptic basal forebrain contains neurons which initiate locomotor stepping. Mapping with low levels of electrical stimulation indicates, but does not prove, that a region centered in the lateral preoptic area might be the location of these neurons. Several lines of evidence indicate that locomotor stepping elicited by electrical stimulation of the hypothalamus is mediated by neurons in the perifornical and lateral hypothalamus. Locomotor effects of hypothalamic stimulation persist in the absence of descending fibers of passage from the ipsilateral preoptic locomotor regions but are severely impaired by kainic acid lesions in the area of stimulation. Injections of glutamate into the perifornical and lateral hypothalamus elicit locomotor stepping at short latencies. Anatomical evidence suggests that the two regions are components of a network for appetitive locomotion. The recognition that multiple systems initiate locomotion both clarifies and complicates the study of locomotion. It provides a framework that incorporates disparate findings but it also underscores the need for increased attention to behavioral issues in studies of locomotor circuitry.
Authors:
H M Sinnamon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Progress in neurobiology     Volume:  41     ISSN:  0301-0082     ISO Abbreviation:  Prog. Neurobiol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-10-28     Completed Date:  1993-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370121     Medline TA:  Prog Neurobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  323-44     Citation Subset:  IM    
Affiliation:
Neuroscience and Behavior Program, Wesleyan University, Middletown, CT 06457.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General*
Animals
Brain Mapping
Electric Stimulation
Glutamates / pharmacology
Glutamic Acid
Hypothalamus / drug effects,  physiology*
Kainic Acid / pharmacology
Locomotion / drug effects,  physiology*
Motivation
Neurons / drug effects,  physiology*
Pentobarbital / pharmacology
Preoptic Area / drug effects,  physiology*
Rats
Wakefulness / physiology
Chemical
Reg. No./Substance:
0/Glutamates; 487-79-6/Kainic Acid; 56-86-0/Glutamic Acid; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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