Document Detail

Preoperative topical moxifloxacin 0.5% and povidone-iodine 5.0% versus povidone-iodine 5.0% alone to reduce bacterial colonization in the conjunctival sac.
MedLine Citation:
PMID:  19969216     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the effectiveness of adding topical moxifloxacin 0.5% to topical povidone-iodine 5.0% for preoperative reduction of bacterial recovery from the conjunctiva. SETTING: Emek Medical Center, Afula, Israel. METHODS: The study population comprised adult patients scheduled for elective intraocular surgery. Two hours before surgery, patients were randomly assigned to topical therapy with moxifloxacin 0.5% drops (study group) or normal saline drops (control group). Povidone-iodine 5% solution was also instilled in the conjunctival sac in both groups for 3 minutes immediately before surgery. Conjunctival cultures were obtained before prophylactic therapy and just before surgery. The major outcome measures were the rate of bacterial colonization and bacterial type in conjunctival cultures obtained after instillation of povidone-iodine and immediately before surgery. RESULTS: Overall, 464 patients completed the study; there were 237 patients in the study group and 227 patients in the control group. Positive conjunctival cultures were obtained before prophylactic therapy in 91 patients (38%) in the study group and 94 patients (41%) in the control group and just before surgery in 10 patients (4%) and 6 patients (3%), respectively; neither difference was statistically significant. Coagulase-negative Staphylococcus was the most prevalent bacteria and was found equally in both groups. CONCLUSIONS: Treatment with povidone-iodine 5.0% alone was effective in preoperative reduction of conjunctival bacterial colonization. Adding topical moxifloxacin 0.5% to povidone-iodine 5.0% had no significant effect on further reduction in the bacterial colonization rate.
Orly Halachmi-Eyal; Orly Halachimi-Eyal; Yaron Lang; Yoram Keness; Dan Miron
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  35     ISSN:  1873-4502     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-08     Completed Date:  2010-02-26     Revised Date:  2010-05-13    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2109-14     Citation Subset:  IM    
Department of Ophthalmology, Emek Medical Center, Afula, Israel.
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MeSH Terms
Administration, Topical
Aged, 80 and over
Anti-Infective Agents, Local / therapeutic use*
Antibiotic Prophylaxis*
Aza Compounds / therapeutic use*
Bacteria / isolation & purification*
Colony Count, Microbial
Conjunctiva / microbiology*
Double-Blind Method
Drug Therapy, Combination
Eye Infections, Bacterial / prevention & control*
Middle Aged
Ophthalmologic Surgical Procedures
Povidone-Iodine / therapeutic use*
Preoperative Care
Prospective Studies
Quinolines / therapeutic use*
Surgical Wound Infection / prevention & control
Young Adult
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Aza Compounds; 0/Quinolines; 0/moxifloxacin; 25655-41-8/Povidone-Iodine
Comment In:
J Cataract Refract Surg. 2010 May;36(5):871; author reply 871-2   [PMID:  20457392 ]
Erratum In:
J Cataract Refract Surg. 2010 Mar;36(3):535
Note: Halachimi-Eyal, Orly [corrected to Halachmi-Eyal, Orly]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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