Document Detail

Preoperative synbiotic bowel conditioning for elective colorectal surgery.
MedLine Citation:
PMID:  20517667     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Preoperative bowel cleaning for elective colorectal surgery is a routine procedure. Synbiotics (probiotics plus prebiotics) are known for their beneficial effects on gut immune function and maintenance of the gut barrier. The main purpose of this study was to replace preoperative mechanical bowel cleaning with synbiotics and to assess the systemic inflammatory response and clinical outcome in patients undergoing colorectal surgery. PATIENTS AND METHODS: A prospective double-blind randomized placebo-controlled trial was conducted in 68 patients. The first group of 20 patients received synbiotics, the second group of 28 patients prebiotics and heat-deactivated probiotics, and the third (control) group of 20 patients mechanical bowel cleaning prior to the operation. RESULTS: Significantly higher values of interleukin 6 (IL-6) were detected 72 h after the operation in the synbiotic group (P = 0.025), as well as an increase of fibrinogen at 24 h postoperatively (P = 0.030). No statistical differences were found in leukocytes count, C-reactive protein or the lymphocyte/granulocyte ratio. There were no differences in postoperative complications between the groups. Mean hospital stay was 9.2 days in the prebiotic group, 9.5 days in the control group, and 10.95 days in the synbiotic group. CONCLUSIONS: Preoperative administration of prebiotics in elective colorectal surgery appears to have the same protective effect in preventing a postoperative inflammatory response as mechanical bowel cleaning. Further prospective studies are needed to verify the effects of synbiotics.
Matjaz Horvat; Bojan Krebs; Stojan Potrc; Arpad Ivanecz; Lidija Kompan
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  122 Suppl 2     ISSN:  1613-7671     ISO Abbreviation:  Wien. Klin. Wochenschr.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  IM    
Department for Abdominal and General Surgery, Clinic for Surgery, University Clinical Center Maribor, Maribor, Slovenia.
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MeSH Terms
Adenocarcinoma / surgery*
Administration, Oral
Aged, 80 and over
Anthraquinones / administration & dosage
C-Reactive Protein / metabolism
Cathartics / administration & dosage
Colorectal Neoplasms / surgery*
Double-Blind Method
Fibrinogen / metabolism
Inflammation Mediators / blood
Interleukin-6 / blood
Leukocyte Count
Middle Aged
Polyethylene Glycols
Postoperative Complications / blood,  prevention & control
Preoperative Care / methods*
Probiotics / administration & dosage*
Prospective Studies
Reg. No./Substance:
0/Anthraquinones; 0/Cathartics; 0/Electrolytes; 0/Golytely; 0/Inflammation Mediators; 0/Interleukin-6; 0/Polyethylene Glycols; 0/Prebiotics; 57828-25-8/X-prep; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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