Document Detail


Preoperative statin administration is associated with lower mortality and decreased need for postoperative hemodialysis in patients undergoing coronary artery bypass graft surgery.
MedLine Citation:
PMID:  19157909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to examine the effect of perioperative statin administration on renal outcomes after cardiac surgery. DESIGN: A retrospective chart review. SETTING: A university hospital. PARTICIPANTS: Patients presenting for cardiac surgery. INTERVENTIONS: The records of 2,760 patients admitted for coronary artery bypass graft (CABG) surgery from 1997 to 2006 were reviewed. In-hospital mortality, the need for renal replacement therapy (RRT), and acute renal failure (ARF) were considered the primary outcomes. Univariate and multiple logistic regression analyses were performed to assess the relationship between each outcome and statin therapy while adjusting for other patient characteristics. MAIN RESULTS: Of the 2,760 patients, 1,557 were taking preoperative statins. On univariate analysis, the mortality rate for patients receiving statins was 2.4% versus 4.2% for those not receiving statins (p = 0.008). The requirement for RRT was 1.9% for patients receiving statins versus 3.6% for those not receiving statins (p = 0.011). The incidence of ARF was not statistically significant between groups (28% v 27.5%). On multivariate analysis, statin therapy was associated with a 43% decrease in the risk of death and a 46% decrease in the risk of RRT, but statins were not associated with a decreased risk of ARF. Also, the beneficial effects of statins were age-dependent, with younger patients experiencing a greater advantage. CONCLUSIONS: The preoperative use of statins is associated with decreased in-hospital mortality and a reduction in the need for RRT.
Authors:
Julie L Huffmyer; William J Mauermann; Robert H Thiele; Jennie Z Ma; Edward C Nemergut
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Publication Detail:
Type:  Journal Article     Date:  2009-01-20
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  23     ISSN:  1532-8422     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-24     Completed Date:  2009-10-05     Revised Date:  2010-09-29    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  468-73     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans
Aged
Aged, 80 and over
Analysis of Variance
Coronary Artery Bypass / mortality*
Creatinine / blood
Ethnic Groups
Female
Glomerular Filtration Rate / physiology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Kidney Failure, Acute / etiology,  mortality
Kidney Function Tests
Male
Middle Aged
Postoperative Complications / epidemiology,  mortality*,  therapy*
Preoperative Care
Renal Dialysis*
Retrospective Studies
Risk Factors
Sex Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 60-27-5/Creatinine
Comments/Corrections
Comment In:
J Cardiothorac Vasc Anesth. 2010 Oct;24(5):904-5; author replly 905-6   [PMID:  20056445 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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