Document Detail

Preoperative pulse wave velocity fails to predict hemodynamic responses to anesthesia and to surgical stimulation.
MedLine Citation:
PMID:  10470628     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To determine whether pulse wave velocity (PWV), which is a useful indicator of cardiovascular disease, can predict the hemodynamic responses to anesthesia and surgical stimulation in surgical patients. DESIGN: Prospective, randomized study. SETTING: Operating rooms at a university hospital. PATIENTS: 30 ASA physical status I and II female patients presenting for elective gynecologic surgery. INTERVENTION: Patients who received one of the following anesthesia techniques were studied; isoflurane, sevoflurane and sevoflurane with nitrous oxide (N2O). MEASUREMENTS AND MAIN RESULTS: Patients underwent preoperative PWV measurements using an automatic PWV measurement device. Systolic blood pressure and heart rate levels were recorded at baseline, during anesthesia, and at skin incision. PWV had no significant correlation with percent changes of systolic blood pressure or heart rate, even after controlling the choice of anesthetic drugs. CONCLUSIONS: Preoperative PWV fails to predict hemodynamic responses to anesthesia and to surgical stimulation.
Y Nakata; T Goto; Y Ishiguro; K Terui; Y Niimi; S Morita
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  11     ISSN:  0952-8180     ISO Abbreviation:  J Clin Anesth     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-10-07     Completed Date:  1999-10-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-9     Citation Subset:  IM    
Department of Anesthesia, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan.
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MeSH Terms
Analysis of Variance
Anesthetics, Inhalation / administration & dosage*
Blood Flow Velocity / drug effects,  physiology
Blood Pressure / drug effects,  physiology
Carotid Arteries / physiology
Femoral Artery / physiology
Gynecologic Surgical Procedures*
Heart Rate / drug effects,  physiology
Hemodynamics / drug effects,  physiology*
Isoflurane / administration & dosage
Methyl Ethers / administration & dosage
Middle Aged
Nitrous Oxide / administration & dosage
Preoperative Care
Prospective Studies
Regression Analysis
Surgical Procedures, Elective
Transducers, Pressure
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane

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