Document Detail


Preoperative oral supplementation with long-chain Omega-3 fatty acids beneficially alters phospholipid fatty acid patterns in liver, gut mucosa, and tumor tissue.
MedLine Citation:
PMID:  15961678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The uptake of omega-3 polyunsaturated fatty acids (PUFAs) into the liver, gut mucosa, and tumor tissue and plasma levels after preoperative administration of supplemented enteral nutrition was investigated in patients with malignancies of the upper gastrointestinal tract. The objective of the study was to evaluate the incorporation of preoperatively administrated PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) into cell phospholipids. METHODS: Patients undergoing major gastrointestinal surgery (n = 40) were prospectively randomized to receive a PUFA-supplemented liquid oral diet 5 days preoperatively or an isocaloric control diet. The planned diet intake was 1000 mL/d providing 3.7 g of PUFA. The diet was given in addition to the usual hospital diet. The phospholipid fractions in plasma were analyzed on the day of surgery. Tissue samples of liver, gut mucosa (small intestine), and tumor were taken during surgery and homogenized. EPA and DHA content was analyzed using liquid gas chromatography. RESULTS: Both patient groups (PUFA group: n = 20; control group: n = 20) were similar in age, weight, and surgical procedures. As compared with the control group, the PUFA group had significantly increased levels of EPA in liver tissue (0.4 vs 1.3 weight %), gut mucosa (0.3 vs 1.0 weight %), and tumor tissue (0.3 vs 0.8 weight %). Also, the DHA levels in the PUFA group were significantly higher than the control group: liver tissue (4.1 vs 7.5 weight %), gut mucosa (2.1 vs 3.7 weight %) and tumor tissue (1.9 vs 4.2 weight %). CONCLUSIONS: This study suggests that administration of PUFA-enriched diets leads to increased incorporation of EPA and DHA not only in liver and gut mucosa tissue, but also in tumor tissue in patients with solid gastrointestinal tumors. Thus, preoperative administration of oral PUFA-enriched diets could have an impact on the postoperative inflammatory response after major abdominal surgery.
Authors:
Metin Senkal; Rolf Haaker; Jakob Linseisen; Günther Wolfram; Heinz-Herbert Homann; Peter Stehle
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  29     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    2005 Jul-Aug
Date Detail:
Created Date:  2005-06-17     Completed Date:  2005-11-04     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  236-40     Citation Subset:  IM    
Affiliation:
Department of Surgery, St. Josef Hospital, Ruhr University, Bochum, Germany. senkal@marien-hospital-witten.de
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Aged
Chromatography, Gas
Dietary Supplements
Docosahexaenoic Acids / administration & dosage,  metabolism,  therapeutic use
Double-Blind Method
Eicosapentaenoic Acid / administration & dosage,  metabolism,  therapeutic use
Enteral Nutrition / methods*
Fatty Acids, Omega-3 / administration & dosage,  therapeutic use*
Female
Gastrointestinal Neoplasms / metabolism,  surgery,  therapy*
Humans
Intestinal Mucosa / metabolism*
Liver / metabolism*
Male
Preoperative Care / methods*
Prospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids

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