| Preoperative multidetector row computed tomography for evaluation and assessment of resection criteria in patients with pancreatic masses. | |
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MedLine Citation:
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PMID: 20929294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: preoperative assessment of pancreatic masses is still challenging as regards the characterization and assessment of irresectability. The opportunities of modern multidetector computed tomography (MDCT) with image postprocessing can be expected to enhance the diagnostic performance if accurate criteria are elaborated. PURPOSE: to estimate the accuracy of MDCT and multiplanar image reconstructions with the use of standardized imaging criteria for preoperative evaluation of pancreatic masses with respect to irresectability. MATERIAL AND METHODS: a total of 105 consecutive patients who underwent exploratory laparoscopy or pancreatic resection and had preoperative 3-phase MDCT (4-64 rows) were enrolled retrospectively. First, transverse sections and secondly additional 3Ds were reviewed by two independent blinded observers (O1/O2). Preoperative imaging findings were correlated with intraoperative and histopathologic results. RESULTS: among all 105 patients, 70 malignant pancreatic tumors and 35 benign pancreatic diseases were found (accuracy of 93% for O1 and 91% for O2). For arterial tumor invasion, receiver operator characteristic (ROC) analysis (values averaged from the results of O1 and O2) revealed an area under the curve (AUC) of 0.931 for transverse sections and 0.986 for 3Ds. Regarding irresectability, positive predictive values were 97% (with 3Ds, 97%) for O1/O2; negative predictive values were 84% (with 3Ds, 89%) for O1 and 86% (with 3Ds, 91%) for O2. CONCLUSION: MDCT with 3Ds was highly accurate for evaluation and assessment of irresectability criteria in patients with pancreatic masses. However, due to the limited specificity regarding arterial tumor infiltration, the indication for surgical exploration should be made generously in case of inconclusive findings. |
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Authors:
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Christian Grieser; Ingo G Steffen; Luise Grajewski; Lars Stelter; Florian Streitparth; Dirk Schnapauff; Matthias Glanemann; Jan Langrehr; Andreas Andreou; Peter Neuhaus; Bernd Hamm; Enrique Lopez Hänninen; Timm Denecke |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2010-10-07 |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 51 ISSN: 1600-0455 ISO Abbreviation: Acta Radiol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-10 Completed Date: 2010-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: England |
Other Details:
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Languages: eng Pagination: 1067-77 Citation Subset: IM |
Affiliation:
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Klinik für Strahlenheilkunde, Viszeral- und Transplantationschirurgie,Campus Virchow-Klinikum, Charit é – Universit ä tsmedizin Berlin, Berlin, Germany. christian.grieser@charite.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Area Under Curve Contrast Media / diagnostic use Female Humans Image Processing, Computer-Assisted / methods Imaging, Three-Dimensional / methods Iohexol / analogs & derivatives, diagnostic use Male Middle Aged Observer Variation Pancreas / radiography, surgery Pancreatic Diseases / radiography, surgery Pancreatic Neoplasms / radiography*, surgery* Predictive Value of Tests Preoperative Care / methods* ROC Curve Radiographic Image Enhancement / methods Reproducibility of Results Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 66108-95-0/Iohexol; 73334-07-3/iopromide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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