Document Detail

Preoperative mechanical bowel preparation does not offer a benefit for patients who undergo pancreaticoduodenectomy.
MedLine Citation:
PMID:  20447669     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Mechanical bowel preparations (MBPs) are commonly administered preoperatively to patients who undergo pancreaticoduodenectomy (PD); however, their effectiveness over a clear liquid diet (CLD) preparation remains unclear. The aim of this study was to determine whether MBP offers an advantage to patients who undergo PD. METHODS: In this retrospective review, we analyzed the clinical data from 100 consecutive PDs performed on patients who received preoperative MBP from March 2006 to April 2007, and we compared them with 100 consecutive patients who received a preoperative CLD from May 2007 to March 2008. RESULTS: No differences were observed between the MBP and CLD groups in the rates of pancreatic fistula (13% vs 14%; P = 1.0), intra-abdominal abscess (11% vs 13%; P = .83), or wound infection (9% vs 8%; P = 1.0). Trends toward increased urinary tract infections (13% vs 5%; P < .08) and Clostridium difficile infections were found in the MBP group (6% vs 1%; P = .12). The median duration of postoperative hospital stay was 7 days in each group, and the 12-month survival rates were equivalent (74% vs 75%; P = 1.0). CONCLUSION: There is no clinical benefit to the administration of a preoperative MBP for patients undergoing PD.
Harish Lavu; Eugene P Kennedy; Ross Mazo; Robert J Stewart; Christopher Greenleaf; Dane R Grenda; Patricia K Sauter; Benjamin E Leiby; Sean P Croker; Charles J Yeo
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-05-05
Journal Detail:
Title:  Surgery     Volume:  148     ISSN:  1532-7361     ISO Abbreviation:  Surgery     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  278-84     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
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MeSH Terms
Abdominal Abscess / prevention & control
Aged, 80 and over
Cathartics / administration & dosage*
Clostridium difficile
Enterocolitis, Pseudomembranous / prevention & control
Length of Stay
Middle Aged
Pancreatic Fistula / prevention & control
Pancreaticoduodenectomy* / adverse effects
Postoperative Complications / prevention & control*
Preoperative Care / methods*
Retrospective Studies
Surgical Wound Infection / prevention & control
Treatment Outcome
Urinary Tract Infections / prevention & control
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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