| Preoperative lymph-node staging of invasive urothelial bladder cancer with (18)F-fluorodeoxyglucose positron emission tomography/computed axial tomography and magnetic resonance imaging: Correlation with histopathology. | |
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MedLine Citation:
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PMID: 21231796 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective. The treatment and prognosis of bladder cancer are based on the depth of primary tumour invasion and the presence of metastases. A highly accurate preoperative tumour, node, metastasis (TNM) staging is critical to proper patient management and treatment. This study retrospectively investigated the value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed axial tomography ((18)F-FDG PET/CT) and magnetic resonance imaging (MRI) for preoperative N staging of bladder cancer. Material and methods. From June 2006 to January 2008, 48 consecutive patients diagnosed with bladder cancer were referred to preoperative staging including MRI and (18)F-FDG PET/CT. Eighteen out of 48 patients underwent radical cystoprostatectomy including removal of lymph nodes for histology, and were included in the study. Values of (18)F-FDG PET/CT and MRI for regional N staging were compared to histopathology findings, the gold standard. Results. (18)F-FDG PET/CT and MRI were performed in 18 patients. The specificities for detection of lymph-node metastases for MRI and (18)F-FDG PET/CT were 80% (n = 15) and 93.33% (n = 15), respectively. The negative predictive values were 80% (n = 15) and 87.5% (n = 16) for MRI and (18)F-FDG PET/CT, respectively. The differences in specificity and negative predictive values were not statistically significant. Conclusions. No significant statistical difference between (18)F-FDG PET/CT and MRI for preoperative N staging of urothelial bladder cancer was found in the study. However, the trend of the data indicates an advantage of (18)F-FDG PET/CT over MRI. Larger prospective studies are needed to elucidate the role of (18)F-FDG PET/CT in N staging of bladder cancer. |
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Authors:
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Thor Knak Jensen; Per Holt; Oke Gerke; Morten Riehmann; Birgitte Svolgaard; Niels Marcussen; Kirsten Bouchelouche |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-13 |
Journal Detail:
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Title: Scandinavian journal of urology and nephrology Volume: - ISSN: 1651-2065 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0114501 Medline TA: Scand J Urol Nephrol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Urology. |
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