Document Detail


Preoperative gender differences in pulmonary gas exchange in morbidly obese subjects.
MedLine Citation:
PMID:  18465177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Morbidly obese men may have poorer pulmonary gas exchange compared to morbidly obese women (see Zavorsky et al., Chest 131:362-367, 2007). The purpose was to compare pulmonary gas exchange in morbidly obese men and women at rest and throughout exercise. METHODS: Twenty-five women (age=38+/-10 years, 164+/-7 cm, body mass index or BMI = 51+/-7 kg/m(2), peak oxygen consumption or VO(2peak)=2.0+/-0.4 l/min) and 17 men (age=43+/-9 years, 178+/-7 cm, BMI=50+/-10 kg/m(2), VO(2peak)=2.6+/-0.8 l/min) were recruited to perform a graded exercise test on a cycle ergometer with temperature-corrected arterial blood-gas samples taken at rest and every minute of exercise, including peak exercise. RESULTS: At rest, women were 98% predicted for pulmonary diffusion compared to 88% predicted in men. At rest, women had better pulmonary gas exchange compared to the men which was related to women having a lower waist-to-hip ratio (WHR; p<0.01). Only 20% of the subjects had an excessive alveolar-to-arterial oxygen partial pressure difference (>or=25 mmHg) at peak exercise, but 75% of the subjects showed inadequate compensatory hyperventilation at peak exercise (arterial carbon dioxide pressure >35 mmHg), and both were not different between genders. CONCLUSION: At rest, morbidly obese men have poorer pulmonary gas exchange and pulmonary diffusion compared to morbidly obese women. The better gas exchange in women is related to the lower WHR in the women. During exercise, few subjects showed disturbances in pulmonary gas exchange despite demonstrating poor compensatory hyperventilation at peak exercise.
Authors:
Gerald S Zavorsky; Nicolas V Christou; Do Jun Kim; Franco Carli; Nancy E Mayo
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Publication Detail:
Type:  Journal Article     Date:  2008-05-09
Journal Detail:
Title:  Obesity surgery     Volume:  18     ISSN:  0960-8923     ISO Abbreviation:  Obes Surg     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106714     Medline TA:  Obes Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1587-98     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, Gynecology and Women's Health, School of Medicine, Saint Louis University, Saint Mary's Health Center, 6420 Clayton Road, Suite 290, Saint Louis, MO 63117, USA. zavorsky@slu.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Composition
Exercise / physiology*
Female
Humans
Male
Middle Aged
Obesity, Morbid / physiopathology*,  surgery
Oxygen Consumption
Pulmonary Diffusing Capacity
Pulmonary Gas Exchange / physiology*
Sex Factors
Waist-Hip Ratio
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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