Document Detail

Preoperative fasting: an outdated concept?
MedLine Citation:
PMID:  15961687     Owner:  NLM     Status:  MEDLINE    
Recent studies have shown that fasting during the preoperative period for elective surgery induces a metabolic state that seems unfavorable for patients. Results from animal studies indicate that rapid depletion of liver glycogen before surgery leads to mobilization of muscle glycogen after surgery, in turn leading to reduced muscle strength. Depletion of liver glycogen also influences the function of the mononuclear phagocytic system (MPS), which is located predominantly in the liver. The MPS is essential in restricting endotoxin, which may translocate from the gut. In addition, surgery per se puts a substantial physical strain on the patient, and fasting may adversely affect the metabolic response to surgery. This paper presents experimental and clinical data that, when combined together, prove that fasting before surgery has adverse consequences for the patient.
J Diks; D E C van Hoorn; R J Nijveldt; P G Boelens; Z Hofman; H Bouritius; Klaske van Norren; P A M van Leeuwen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  29     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    2005 Jul-Aug
Date Detail:
Created Date:  2005-06-17     Completed Date:  2005-11-04     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  298-304     Citation Subset:  IM    
Department of Surgery, VU Medisch Centrum (Free University Medical Centre), Amsterdam, The Netherlands.
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MeSH Terms
Disease Models, Animal
Fasting / adverse effects*,  metabolism,  physiology*
Glycogen / metabolism*
Liver Glycogen / metabolism
Muscle, Skeletal / metabolism
Preoperative Care / methods*
Reg. No./Substance:
0/Liver Glycogen; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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