| Preoperative diagnosis of coronary artery disease in patients with valvular heart disease using technetium-99m isonitrile tomographic imaging together with high-dose dipyridamole and handgrip exercise. | |
| | |
MedLine Citation:
|
PMID: 1590234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Forty-seven consecutive patients (mean age 61 +/- 8 years) referred for cardiac catheterization due to moderate to severe aortic (n = 30) or mitral (n = 17) valvular heart disease were examined by technetium-99m isonitrile tomography together with a high-dose dipyridamole infusion (0.7 mg/kg) and handgrip stress. Tomography did not identify coronary artery disease (CAD) in 3 of the 21 patients with angiographically proven disease (sensitivity 86%) and suggested false positive results in 5 of the 26 without the disease (specificity 81% and negative predictive accuracy 88%). No patient without angina pectoris and with negative scintigraphy (n = 14) had angiographically significant (greater than or equal to 50% diameter stenosis) CAD. Overall vessel sensitivity was 63%, and specificity was 92%. The frequency of side effects during the dipyridamole-handgrip test was only 7%. No serious complications occurred during stress tests. Thus, technetium-99m isonitrile tomographic imaging, together with high-dose dipyridamole and handgrip exercise, is a useful noninvasive method in excluding significant CAD in patients with valvular heart disease. |
| | |
Authors:
|
R Kettunen; H V Huikuri; J Heikkilä; J T Takkunen |
Related Documents
:
|
12911874 - Relationship between ace gene polymorphism and ischemic chronic heart failure in turkis... 3149044 - Circadian fluctuations of plasminogen activator inhibitor and tissue plasminogen activa... 8088314 - Lysine-binding species of lipoprotein(a) in coronary artery disease. 20724904 - Coronary artery phenotypes in subjects with negative myocardial perfusion imaging and t... 19157594 - A case of very late stent thrombosis facilitated by drug eluting stent fracture: compar... 20337244 - Changing patterns of cardiovascular risk factors and heart related sickness in relation... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of cardiology Volume: 69 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1992 Jun |
Date Detail:
|
Created Date: 1992-06-24 Completed Date: 1992-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1442-5 Citation Subset: AIM; IM; S |
Affiliation:
|
Department of Medicine, Oulu University Central Hospital, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Coronary Angiography Coronary Disease / complications, radiography, radionuclide imaging* Dipyridamole / adverse effects, diagnostic use* Exercise Test* / adverse effects Female Heart Valve Diseases / complications*, surgery Humans Male Middle Aged Nitriles / diagnostic use* Organotechnetium Compounds / diagnostic use* Predictive Value of Tests Sensitivity and Specificity Technetium Tc 99m Sestamibi Tomography, Emission-Computed* |
| Chemical | |
Reg. No./Substance:
|
0/Nitriles; 0/Organotechnetium Compounds; 109581-73-9/Technetium Tc 99m Sestamibi; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of direct, reflex and exercise-provoked increases in sympathetic tone on idiopathic ventricul...
Next Document: Frequency of magnetic resonance signal abnormalities of the brain in patients aged less than 50 year...