Document Detail

Preoperative clonidine blunts hyperadrenergic and hyperdynamic responses to prolonged tourniquet pressure during general anesthesia.
MedLine Citation:
PMID:  11867385     Owner:  NLM     Status:  MEDLINE    
IMPLICATIONS: Tourniquet inflation is associated with a continuous increase in arterial blood pressure and sympathetic outflow. This study shows that IV clonidine effectively blunts increases of both arterial blood pressure and plasma norepinephrine concentrations.
Marco P Zalunardo; Daniel Serafino; Patricia Szelloe; Fabia Weisser; Andreas Zollinger; Burkhardt Seifert; Thomas Pasch
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  94     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-27     Completed Date:  2002-03-21     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  615-8; table of contents     Citation Subset:  AIM; IM    
Institute of Anesthesiology, University Hospital, Zürich, Switzerland.
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MeSH Terms
Anesthesia, General*
Blood Pressure / drug effects*
Clonidine / pharmacology*
Double-Blind Method
Middle Aged
Multivariate Analysis
Norepinephrine / blood*
Reg. No./Substance:
4205-90-7/Clonidine; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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