Document Detail

Preoperative chemotherapy, surgical resection, and selective postoperative therapy for squamous cell carcinoma of the esophagus.
MedLine Citation:
PMID:  3355277     Owner:  NLM     Status:  MEDLINE    
In an attempt to improve on the long-term survival rate of patients with esophageal squamous cell carcinoma, we designed a study in which treatment included preoperative chemotherapy with fluorouracil and cisplatin, surgical resection, and selective postoperative chemotherapy or radiation therapy. Between 1981 and 1986, 35 patients with potentially resectable lesions were entered into the study. After chemotherapy, 13 of 35 patients (37%) had a complete clinical response, 7 (20%) had a partial response, and 15 (43%) had no response. One patient sustained a serious toxic reaction (renal failure). Twenty-seven patients underwent surgical resection, with 1 hospital death (3.7%). Selective postoperative radiotherapy or chemotherapy was administered to 69%. The actuarial survival of all resected patients at 42 months was 54% (standard error, 10%). Multivariate analysis showed significant factors associated with 3-year survival were: (1) complete clinical response to chemotherapy; (2) absence of wall penetration in the specimen; and (3) microscopic or no disease in the specimen. We conclude that this multimodality treatment method improves the intermediate-term survival of patients with squamous cell carcinoma of the esophagus.
A D Hilgenberg; R W Carey; E W Wilkins; N C Choi; D J Mathisen; H C Grillo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  45     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-05-05     Completed Date:  1988-05-05     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-63     Citation Subset:  AIM; IM    
Surgical Services, Massachusetts General Hospital, Boston 02114.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Carcinoma, Squamous Cell / drug therapy,  mortality,  surgery,  therapy*
Cisplatin / administration & dosage
Combined Modality Therapy
Esophageal Neoplasms / drug therapy,  mortality,  surgery,  therapy*
Fluorouracil / administration & dosage
Reg. No./Substance:
15663-27-1/Cisplatin; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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