| Preoperative autologous blood donation reduces the need for allogeneic blood products: a prospective randomized study. | |
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MedLine Citation:
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PMID: 19057729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We sought to assess the efficacy of preoperative autologous blood donation in reducing patient exposure to allogeneic blood products following elective cardiac surgery. METHODS: We included 48 patients in a prospective study and randomly assigned them into the control or treatment group. We excluded patients with aortic stenosis, main trunk stenosis and unstable angina. Group A (n=23; coronary disease n=21 and valvular disease n=2) was the control group, and group B (n=25; coronary disease n=21, valvular disease n=4) received preoperative autologous blood donation. All patients had cardiopulmonary bypass surgery, and we processed mediastinal blood with a cell-saver device before reinfusion. All patients received aprotinin, and we reinfused blood shed from the mediastinum postoperatively. RESULTS: No major peri- or postoperative complications occurred. We interrupted preoperative blood donation in 2 patients (8%) because of worsened angina pectoris. The mean time between the first blood donation and surgery was 22.5 (standard deviation [SD] 9.4, range 12-50) days. In group A, 9 patients (39.1%) were exposed to allogeneic blood products. In group B, 11 patients (47.8%) were exposed to blood products (p=0.73), and 4 (16%) were exposed to allogeneic blood products (p=0.036). CONCLUSION: Preoperative blood donation was completed in 92% of the targeted low-risk population. The procedure significantly reduced exposure to perioperative allogeneic blood products. |
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Authors:
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Denis Bouchard; Bertrand Marcheix; Sfoug Al-Shamary; Frédéric Vanden Eynden; Philippe Demers; Danielle Robitaille; Michel Pellerin; Louis P Perrault; Michel Carrier |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Canadian journal of surgery. Journal canadien de chirurgie Volume: 51 ISSN: 1488-2310 ISO Abbreviation: Can J Surg Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-05 Completed Date: 2008-12-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372715 Medline TA: Can J Surg Country: Canada |
Other Details:
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Languages: eng Pagination: 422-7 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Montreal Heart Institute, Montréal, Quebec. denis.bouchard@icm-mhi.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Donors* Blood Transfusion Blood Transfusion, Autologous* Cardiac Surgical Procedures* Female Heart Diseases / surgery Humans Male Middle Aged Preoperative Care Prospective Studies Transplantation, Homologous |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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