| Preoperative autologous blood donation - part I. Only two clinical parameters determine efficacy of the autologous predeposit. | |
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MedLine Citation:
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PMID: 17384572 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To improve efficacy of preoperative autologous blood donation (i.e. increase in total RBC-mass) it is important to know those clinical parameters that are of decisive impact for it. METHODS: Prospective study in 704 patients scheduled for major orthopaedic surgery. Donation of either one or two separately collected RBC-units, and calculation of increase in RBC-mass by the HCT-method. Qualitative statistical analysis by multiple univariate analysis of variances, correlation analysis with Pearson, multiple linear regression analysis. Quantitative statistical analysis by t-/U-test; P<0.01(n >or= 100), and P<0.05 (n <100), respectively. RESULTS: Two parameters were demonstrated of decisive impact to increase in RBC-mass to preopeative autologous blood donation (PABD) (P<0.000): first, time interval between preoperative autologous blood donation and surgery, that correlated positively with efficacy; second, haematocrit-level at predeposit-session that correlated negatively with efficacy. The highest level of RBC-regeneration reached was observed four weeks after last blood donation (one unit:146.6+/-85.2 mL; two units: 297.4+/-78.6 mL). Patients with an anaemic initial haematocrit (females: <or=37%; males <or=40%) generated more RBC (*P<0.05) than non-anaemic patients (one unit: females, 148.3+/-67.6 vs 73.8+/-65.8 mL; males, 170.5+/-81.6 vs 77.0+/- 93.9 mL. Two units: females, 295.0+/-58.5 vs 226.0+/-79.7 mL; males, 299.9+/-82.5 vs 234.6+/- 107.5 mL). CONCLUSIONS: To improve efficacy of preoperative autologous blood donation, a time interval between (last) autologous predeposit and surgery of at least 4 weeks should remain for efficacious RBC-regeneration; together with an acute and strong decline in haematocrit due to the autologous predeposit to push erythropoiesis as efficaciously as possible. |
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Authors:
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G Singbartl |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Minerva anestesiologica Volume: 73 ISSN: 0375-9393 ISO Abbreviation: Minerva Anestesiol Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-26 Completed Date: 2007-07-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375272 Medline TA: Minerva Anestesiol Country: Italy |
Other Details:
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Languages: eng Pagination: 143-51 Citation Subset: IM |
Affiliation:
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AIT - Institut fuer Anaesthesie, Intensiv- und Transfusionsmedizin, ENDO-Klinik Hamburg GmbH, Hamburg, Germany. g.singbartl@gmx.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Transfusion, Autologous* Erythrocyte Count Female Hematocrit Humans Male Middle Aged Orthopedic Procedures Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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