Document Detail

Preoperative administration of excess iodide increases thyroid volume of patients with Graves' disease.
MedLine Citation:
PMID:  19139595     Owner:  NLM     Status:  MEDLINE    
Preoperative excess iodide administration for patients with Graves' disease has been widely adopted by surgeons to perform surgery safely, because it decreases blood flow in the thyroid. However, surgeons often encounter the enlargement of thyroid volume after iodide administration, which makes surgery even more difficult. In this study, we retrospectively investigated the change in thyroid volume in Graves' disease that was evaluated on ultrasonography between before and after iodide administration. Eighty-nine patients who received iodide administered (KI(+) patients) and 24 in whom iodide was not administrated (KI(-) patients) before surgery for Graves' disease were enrolled in the study. The level of free T4 (FT4) significantly decreased and that of thyroid stimulating hormone (TSH) significantly increased after iodide administration. Average thyroid volume also significantly increased for KI(+) patients after iodide administration and 17% of these patients showed a 30% or more increase in thyroid volume. In KI(-) patients who were preoperatively treated only by anti-thyroid drugs, thyroid volume did not change before surgery. Preoperative TSH levels remained below measurement sensitivity in 37 of KI(+) patients, but the average thyroid volume also significantly increased after iodide administration. These findings suggest that thyroid volume in Graves' disease can increase with iodide administration not only due to TSH stimulation but also due to reasons other than TSH. Surgeons should be careful when preoperatively iodide administering to patients with Graves' disease, especially when the goiter is large.
Tomonori Yabuta; Yasuhiro Ito; Mitsuyoshi Hirokawa; Mitsuhiro Fukushima; Hiroyuki Inoue; Chisato Tomoda; Takuya Higashiyama; Minoru Kihara; Takashi Uruno; Yuuki Takamura; Kaoru Kobayashi; Akihiro Miya; Fumio Matsuzuka; Akira Miyauchi
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Publication Detail:
Type:  Journal Article     Date:  2009-01-09
Journal Detail:
Title:  Endocrine journal     Volume:  56     ISSN:  1348-4540     ISO Abbreviation:  Endocr. J.     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-09-04     Revised Date:  2011-06-16    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  371-5     Citation Subset:  IM    
Department of Surgery, Kuma Hospital, Kobe, Japan.
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MeSH Terms
Graves Disease / drug therapy,  pathology,  surgery*,  ultrasonography
Potassium Iodide / administration & dosage,  adverse effects,  therapeutic use
Preoperative Care
Retrospective Studies
Thyroid Gland / pathology*,  ultrasonography*
Reg. No./Substance:
7681-11-0/Potassium Iodide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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