| Preoperative administration of esomeprazole has no influence on frequency of refluxes. | |
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MedLine Citation:
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PMID: 18502362 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: To examine the effect of esomeprazole in a fixed time setting on gastric content volume, gastric acidity, gastric barrier pressure, and reflux propensity. DESIGN: Randomized, controlled, double-blind trial. SUBJECTS: 21 healthy, ASA I physical status volunteers. INTERVENTION: Esomeprazole was given 12 hours and one hour before investigation. Before the study, a multichannel intraluminal impedance catheter, pH monitoring data logger (PHmetry) catheter, and an intragastric-esophageal manometry catheter were placed nasally after topical anesthesia. MEASUREMENTS: Gastric acidity and gastric content volume were determined by PHmetry after aspiration of gastric contents over a nasogastric tube. Gastroesophageal reflux and intragastric-esophageal barrier pressure were investigated by multichannel intraluminal impedance measurement, PHmetry, and intragastric-esophageal manometry. MAIN RESULTS: The pH of gastric contents was significantly (P < 0.001) higher after esomeprazole (mean [25th-75th percentile], 4.2 [3.9-4.8] vs 2.0 [1.9-2.7]), and gastric content volume was significantly (P < 0.001) lower (5.0 mL [3.0-12.0] vs 15 mL [10.0-25.0]) in comparison to placebo. No significant difference between esomeprazole and placebo was found with respect to number of refluxes per person, duration of reflux, or barrier pressure. CONCLUSION: Esomeprazole in a fixed time setting can markedly increase the pH of gastric contents and decrease gastric content volume, but has no influence on the frequency, duration of refluxes, or gastroesophageal barrier pressure. |
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Authors:
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Hans-Christian Jeske; Jan Borovicka; Achim von Goedecke; Werner Tiefenthaler; Matthias Hohlrieder; Thomas Heidegger; Arnulf Benzer |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical anesthesia Volume: 20 ISSN: 0952-8180 ISO Abbreviation: J Clin Anesth Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-26 Completed Date: 2008-10-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8812166 Medline TA: J Clin Anesth Country: United States |
Other Details:
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Languages: eng Pagination: 191-5 Citation Subset: IM |
Affiliation:
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Department of Traumatology and Sports Medicine, Innsbruck Medical University, A-6020 Innsbruck, Austria. hans.jeske@i-med.ac.at <hans.jeske@i-med.ac.at> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Ulcer Agents / therapeutic use* Double-Blind Method Electric Impedance Female Gastric Acidity Determination Gastroesophageal Reflux / prevention & control* Gastrointestinal Contents Humans Hydrogen-Ion Concentration Male Manometry Omeprazole / therapeutic use* Pressure |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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