Document Detail


Preoperative predictors of significant symptomatic response after 1 year of gastric electrical stimulation for gastroparesis.
MedLine Citation:
PMID:  20411386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In cases of gastroparesis where significant symptoms fail to respond to standard medical therapy, gastric electrical stimulation (GES) may be of benefit. Unfortunately, not all patients improve with this therapy. Reliable preoperative predictors of symptomatic response to GES may allow clinicians to offer this expensive and invasive treatment to only those patients most likely to benefit. METHODS: Therapy was initiated in 15 patients more than 12 months prior to this retrospective review of our prospectively maintained data. All patients completed a Total Symptom Score (TSS) survey at every encounter as well as the SF-36 quality-of-life instrument prior to surgery. A failure of GES therapy was considered to have occurred when after 1 year of treatment, preoperative TSS had not decreased by at least 20%. RESULTS: Four patients (4 idiopathic) failed to improve more than 20% on multiple assessments after a year of therapy. All diabetic patients experienced a durable symptomatic improvement with GES. Review of individual items of the TSS revealed that nonresponders experienced less severe vomiting preoperatively. CONCLUSIONS: Diabetic gastroparesis patients respond best to GES. Responders tend to have more severe vomiting preoperatively. Patients with idiopathic gastroparesis who do not experience severe vomiting should be cautioned about a potentially higher rate of poor response to GES and may be better served with alternative treatments.
Authors:
Sandeepa Musunuru; Gretchen Beverstein; Jon Gould
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of surgery     Volume:  34     ISSN:  1432-2323     ISO Abbreviation:  World J Surg     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1853-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Wisconsin School of Medicine and Public Health, H4/726 Clinical Science Center, 600 Highland Avenue, Madison, WI, 53792, USA. SMusunuru@uwhealth.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Diabetes Complications / radionuclide imaging,  therapy
Electric Stimulation Therapy* / adverse effects
Female
Gastroparesis / etiology,  radionuclide imaging,  therapy*
Humans
Male
Middle Aged
Predictive Value of Tests
Quality of Life
Retrospective Studies
Statistics, Nonparametric
Treatment Outcome
Vomiting / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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