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Preoperative Diagnosis of Orbital Cavernous Hemangioma: A 99mTc-RBC SPECT Study.
MedLine Citation:
PMID:  23047756     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: This study aimed to describe Tc-labeled RBC scintigraphy as a diagnostic method for orbital cavernous hemangiomas and to evaluate this diagnostic tool according to surgical outcomes.
METHODS: Fifty-five patients with clinical and radiological (US, CT, and/or MRI) suspicion of unilateral cavernous hemangioma of the orbit underwent Tc-RBC SPECT study.Qualitative and semiquantitative evaluations were performed, and results were statistically analyzed.
RESULTS: SPECT images showed focal uptake in the orbital mass in 36 of 55 patients. Nineteen patients had a negative scintigraphic pattern, with concordance of early and late absence of uptake of Tc-RBC.Our procedure showed 100% sensitivity and 88.9% specificity for the diagnosis of orbital cavernous hemangioma, with a positive predictive value of 90.9% and a negative predictive value of 100%.
CONCLUSIONS: Tc-RBC imaging is safe, easy to perform, and highly accurate in providing adequate clinical and surgical management. As a noninvasive and highly specific method for diagnosing orbital hemangioma, Tc-RBC scintigraphy can avoid more invasive imaging or biopsy.
Luca Burroni; Giulia Borsari; Patrizia Pichierri; Ennio Polito; Olga Toscano; Gaia Grassetto; Adil Al-Nahhas; Domenico Rubello; Angelo Giuseppe Vattimo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  37     ISSN:  1536-0229     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1041-6     Citation Subset:  IM    
From the Departments of *Nuclear Medicine and †Ophthalmology, University of Siena, Santa Maria alle Scotte Hospital, Siena; ‡Department of Nuclear Medicine, Santa Maria della Misericordia Hospital, Rovigo, Italy and §Department of Nuclear Medicine, Hammersmith Hospital, London, UK.
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