Document Detail

Preoperative C-reactive protein is predictive of long-term outcome after coronary artery bypass surgery.
MedLine Citation:
PMID:  16682213     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Increased levels of C-reactive protein (CRP) are associated with the presence and severity of atherosclerosis, and with increased risk of coronary events as well as of cardiac events after coronary percutaneous intervention. METHODS: We have investigated whether preoperative CRP had an impact on the long-term outcome of 843 patients who underwent on-pump coronary artery bypass surgery (CABG). RESULTS: Among operative survivors, patients with preoperative CRP < 1.0 mg/dL had significantly better 12-year overall survival rate (74.1% vs 63.0%, p = 0.004) and survival freedom from fatal cardiac event (86.7% vs 78.1%). Multivariate analysis including patients' age, extracardiac arteriopathy, urgent/emergent operation, recent myocardial infarction, congestive heart failure, left ventricular ejection fraction, atrial fibrillation, transient ischemic attack/stroke, number of distal anastomoses, diabetes, and preoperative CRP > or = 1.0 mg/dL or <1.0 mg/dL, showed that the latter was an independent predictor of late all-cause mortality (p = 0.017, RR 1.60, 95% CI 1.09-2.35). Its impact on overall survival was particularly evident in patients with left ventricular ejection fraction <50% (CRP < 1.0 mg/dL: 58.7% vs CRP > or = 1.0 mg/dL: 43.7%, p < 0.00001). CONCLUSIONS: Increased preoperative levels of CRP are associated with significantly decreased overall survival after primary on-pump CABG.
Olli-Pekka Kangasniemi; Fausto Biancari; Johannes Luukkonen; Sailaritta Vuorisalo; Jari Satta; Risto Pokela; Tatu Juvonen
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Publication Detail:
Type:  Journal Article     Date:  2006-05-08
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  29     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-23     Completed Date:  2007-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  983-5     Citation Subset:  IM    
Division of Cardio-thoracic and Vascular Surgery, Department of Surgery, Oulu University Hospital, P.O. Box 21, 90029 Oulu, Finland.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / analysis*
Coronary Artery Bypass* / mortality
Coronary Disease / blood*,  surgery
Epidemiologic Methods
Finland / epidemiology
Middle Aged
Preoperative Care / methods
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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